SULT1C4 Human

Sulfotransferase Family, Cytosolic 1C, Member 4 (SULT1C4) is a member of the sulfotransferase (SULT) enzyme family. These enzymes play a crucial role in the metabolism of various endogenous and exogenous compounds by catalyzing the sulfate conjugation of hormones, neurotransmitters, drugs, and xenobiotic compounds . SULT1C4 is a protein-coding gene that belongs to the SULT1 subfamily, which is responsible for transferring a sulfo moiety from 3’-phospho-5’-adenylyl sulfate (PAPS) to phenol-containing compounds .

The gene structure of SULT1C4, including the number and length of exons, is similar among family members . SULT1C4 is expressed in various tissues, and its expression pattern is distinct from other members of the SULT family. The gene is located on chromosome 2 and has several aliases, including SULT1C2 and ST1C4 .

SULT1C4 utilizes PAPS as a sulfonate donor to catalyze the sulfate conjugation of phenolic compounds . It can also sulfonate estrogenic compounds, although dietary flavonoids (phytoestrogens) and environmental estrogens, such as bisphenol A, are better substrates than 17beta-estradiol (E2) . Additionally, SULT1C4 mediates the sulfation of doxorubicin and its analog epirubicin, two antitumor anthracyclines .

Diseases associated with SULT1C4 include spondyloepiphyseal dysplasia with congenital joint dislocations and ovary sarcoma . The enzyme’s role in the metabolism of various compounds makes it a potential target for drug development and therapeutic interventions.

Recombinant human SULT1C4 is used in research to study its enzymatic activity, substrate specificity, and potential therapeutic applications. Understanding the function and regulation of SULT1C4 can provide insights into its role in drug metabolism and the development of novel treatments for diseases associated with its dysfunction.