STRADA Human
Description
STRADA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
STRADA consists almost entirely of an STE20-like kinase domain but lacks several residues essential for intrinsic catalytic activity, classifying it as a pseudokinase . Despite its lack of catalytic activity, STRADA forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium-binding protein 39 (CAB39, also known as MO25) . This complex is essential for the activation of STK11, leading to the phosphorylation of both proteins and excluding STK11 from the nucleus .
The primary function of STRADA is to act as a pseudosubstrate for STK11/LKB1, promoting its conformational change into an active state . This activation is crucial for STK11-induced G1 cell cycle arrest, which is a vital process in preventing uncontrolled cell proliferation . Additionally, STRADA is involved in several signaling pathways, including the mTOR signaling and PI3K-Akt signaling pathways, which are critical for cell growth, survival, and metabolism .
Mutations in the STRADA gene have been associated with Polyhydramnios, Megalencephaly, and Symptomatic Epilepsy (PMSE) syndrome . This rare genetic disorder is characterized by an excess of amniotic fluid during pregnancy, an abnormally large brain, and recurrent seizures . Understanding the role of STRADA in these conditions can provide insights into potential therapeutic targets for treating such disorders.
