STK3 Human
Description
STK3 is fused to a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
STK3 is involved in several key cellular functions, including the regulation of cell proliferation, apoptosis, and differentiation. It plays a significant role in the Hippo signaling pathway, which is essential for controlling organ size by regulating cell growth, apoptosis, and stem cell self-renewal .
STK3 is ubiquitously expressed in various tissues, with higher expression levels observed in the pancreas, heart, placenta, lung, and kidney. It is also detected at lower levels in other tissues . The expression of STK3 can vary significantly in different types of cancers, with notable increases in colorectal and lung cancers .
The primary function of STK3 is to act as a tumor suppressor by regulating cell proliferation and apoptosis. It achieves this by phosphorylating and activating downstream components of the Hippo signaling pathway, such as LATS1/2 kinases, which in turn phosphorylate and inhibit the transcriptional co-activators YAP and TAZ .
STK3 functions through the Hippo signaling pathway. When activated, it forms a complex with other kinases, leading to the phosphorylation and activation of LATS1/2. This activation results in the phosphorylation of YAP/TAZ, preventing their translocation to the nucleus and subsequent activation of target genes involved in cell proliferation and survival .
The activity of STK3 is regulated by various mechanisms, including phosphorylation, ubiquitination, and interaction with other proteins. For instance, STK3 can be phosphorylated and activated by upstream kinases such as MST1. Additionally, it can undergo ubiquitination, leading to its degradation by the proteasome .
Given its role in regulating cell proliferation and apoptosis, STK3 is considered a potential target for cancer therapy. Dysregulation of STK3 and the Hippo pathway has been implicated in the development and progression of various cancers. Therapeutic strategies aimed at modulating STK3 activity could provide new avenues for cancer treatment .
