STK17A Human

Serine/Threonine Kinase 17A Human Recombinant
Cat. No.
BT22451
Source
Escherichia Coli.
Synonyms
DRAK1, Serine/threonine-protein kinase 17A, DAP kinase-related apoptosis-inducing protein kinase 1, STK17A.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

STK17A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 281 amino acids (64-321 a.a) and having a molecular mass of 31.9kDa.STK17A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
STK17A, a member of the DAP kinase-associated apoptosis-inducing protein kinase family, encodes a self-phosphorylating nuclear protein with a protein kinase domain. This protein functions as a positive regulator of apoptosis and is highly expressed in the placenta. Lower expression levels are observed in the heart, lung, skeletal muscle, kidney, and pancreas.
Description
Recombinant human STK17A, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 281 amino acids (residues 64-321). With a molecular weight of 31.9 kDa, it includes a 23 amino acid His-tag fused at the N-terminus. Purification is achieved through proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The STK17A protein solution (0.5 mg/ml) is supplied in a buffer containing 20 mM Tris-HCl (pH 8.0), 10% glycerol, and 0.4 M Urea.
Stability
For short-term storage (2-4 weeks), the solution should be kept at 4°C. For extended storage, freezing at -20°C is recommended. The addition of a carrier protein (0.1% HSA or BSA) is advisable for long-term storage. Repeated freeze-thaw cycles should be avoided.
Purity
The purity is determined to be greater than 80.0% by SDS-PAGE analysis.
Synonyms
DRAK1, Serine/threonine-protein kinase 17A, DAP kinase-related apoptosis-inducing protein kinase 1, STK17A.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSGRELGRG KFAVVRKCIK KDSGKEFAAK FMRKRRKGQD CRMEIIHEIA VLELAQDNPW VINLHEVYET ASEMILVLEY AAGGEIFDQC VADREEAFKE KDVQRLMRQI LEGVHFLHTR DVVHLDLKPQ NILLTSESPL GDIKIVDFGL SRILKNSEEL REIMGTPEYV APEILSYDPI SMATDMWSIG VLTYVMLTGI SPFLGNDKQE TFLNISQMNL SYSEEEFDVL SESAVDFIRT LLVKKPEDRA TAEECLKHPW L.

Product Science Overview

Overview

Serine/Threonine Kinase 17A (STK17A), also known as DRAK1 (Death-Associated Protein Kinase-Related 1), is a member of the death-associated protein (DAP) kinase family. This family of kinases is known for its role in regulating apoptosis, a form of programmed cell death crucial for maintaining cellular homeostasis .

Gene and Protein Structure

The STK17A gene is located on chromosome 7 (7p13) and encodes a protein that is approximately 45 kDa in size . The protein contains a kinase domain that is responsible for its enzymatic activity, specifically transferring phosphate groups to serine/threonine residues on substrate proteins .

Function

STK17A plays a significant role in apoptosis and cellular stress responses. It is an autophosphorylated nuclear protein that can induce apoptosis through its kinase activity . Additionally, STK17A has been implicated in the regulation of reactive oxygen species (ROS) within cells, further highlighting its role in cellular stress responses .

Regulation and Pathways

STK17A is a target gene of the tumor suppressor protein p53, which is activated in response to DNA damage . This regulation underscores the importance of STK17A in the cellular response to genotoxic stress. The protein is also involved in various signaling pathways, including those related to sweet taste signaling .

Clinical Relevance

Given its role in apoptosis and cellular stress responses, STK17A is of interest in cancer research. Its ability to induce apoptosis makes it a potential target for therapeutic interventions aimed at promoting the death of cancer cells . Moreover, recent studies have suggested that STK17A may play a role in the longevity of centenarians, indicating its broader significance in human health .

Research and Applications

Recombinant human STK17A is used in various research applications to study its function and regulation. This includes investigating its role in apoptosis, ROS regulation, and its potential as a therapeutic target in cancer .

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