STK11 Human
Escherichia Coli.
Serine/threonine-protein kinase STK11, Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19, STK11, LKB1, PJS
Greater than 85.0% as determined by SDS-PAGE.
Description
STK11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-433) and having a molecular mass of 51kDa.
STK11 is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
Serine/threonine-protein kinase STK11, Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19, STK11, LKB1, PJS
Escherichia Coli.
MGSSHHHHHH SSGLVPRGSH MGSMEVVDPQ QLGMFTEGEL MSVGMDTFIH RIDSTEVIYQ PRRKRAKLIG KYLMGDLLGE GSYGKVKEVL DSETLCRRAV KILKKKKLRR IPNGEANVKK EIQLLRRLRH KNVIQLVDVL YNEEKQKMYM VMEYCVCGMQ EMLDSVPEKR FPVCQAHGYF CQLIDGLEYL HSQGIVHKDI KPGNLLLTTG GTLKISDLGV AEALHPFAAD DTCRTSQGSP AFQPPEIANG LDTFSGFKVD IWSAGVTLYN ITTGLYPFEG DNIYKLFENI GKGSYAIPGD CGPPLSDLLK GMLEYEPAKR FSIRQIRQHS WFRKKHPPAE APVPIPPSPD TKDRWRSMTV VPYLEDLHGA DEDEDLFDIE DDIIYTQDFT VPGQVPEEEA SHNGQRRGLP KAVCMNGTEA AQLSTKSRAE GRAPNPARKA CSASSKIRRL SACKQQ
Product Science Overview
The STK11 gene is located on chromosome 19 in humans . The protein encoded by this gene is a serine/threonine kinase, which means it phosphorylates serine and threonine residues on target proteins. This phosphorylation is essential for the activation or deactivation of these target proteins, thereby regulating their function.
STK11/LKB1 is a primary upstream kinase of the AMP-activated protein kinase (AMPK) family . It phosphorylates the T-loop of AMPK family proteins, promoting their activity. This phosphorylation is crucial for maintaining cellular energy homeostasis, especially under conditions of low energy . Some of the key processes regulated by STK11 include:
- Cell Metabolism: STK11 regulates glucose homeostasis in the liver and activates autophagy during nutrient deprivation .
- Cell Polarity: It maintains cell polarity, which is vital for the proper organization and function of cells .
- Tumor Suppression: STK11 acts as a tumor suppressor by inhibiting signaling pathways that promote cell growth and proliferation when energy levels are low .
Mutations in the STK11 gene are associated with several diseases, including:
Given its role in regulating critical cellular processes, STK11 is a significant focus of research. Understanding its function and regulation can provide insights into developing therapeutic strategies for diseases associated with its dysfunction, particularly cancer.
