STAC Human
Description
STAC is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The SH3 and Cysteine Rich Domain, often abbreviated as STAC, is a protein coding gene that plays a crucial role in various cellular processes. This domain is characterized by the presence of Src Homology 3 (SH3) and cysteine-rich regions, which are essential for its function in cellular signaling and protein interactions.
The SH3 domain is a small protein module consisting of approximately 60 amino acids. It is arranged in a compact β-barrel fold made up of five β-strands connected by loops and a 3_10-helix . The SH3 domain is known for its ability to mediate protein-protein interactions by binding to proline-rich motifs in partner proteins. This interaction is critical for the assembly of protein complexes involved in various biological processes, including cell survival, proliferation, differentiation, migration, and polarity .
The cysteine-rich domain, on the other hand, is involved in the regulation of protein localization and activity. It plays a significant role in the positive regulation of voltage-gated calcium channel activity and skeletal muscle contraction . The STAC gene, which encodes the SH3 and cysteine-rich domain-containing protein, is specifically expressed in skeletal muscle and is essential for muscle development and function .
The SH3 and cysteine-rich domain-containing proteins are implicated in several physiological pathways and are associated with various diseases. For instance, mutations in the STAC3 gene have been linked to congenital myopathy, a condition characterized by muscle weakness and developmental delays . Additionally, the SH3 domain is involved in the development of diseases such as cancer, leukemia, osteoporosis, Alzheimer’s disease, and various infections .
Research on SH3 and cysteine-rich domains has provided valuable insights into their role in cellular signaling and disease mechanisms. The ability of SH3 domains to mediate protein-protein interactions makes them potential targets for drug development. By targeting these interactions, it may be possible to develop therapies for diseases associated with SH3 domain dysfunction .
In the context of recombinant protein technology, human recombinant SH3 and cysteine-rich domain proteins are used in various research applications. These include studying protein interactions, understanding disease mechanisms, and developing potential therapeutic interventions.
