ST13 PAT5C6AT Antibody

HSP70 Interacting Protein Clone PAT5C6AT, Mouse Anti Human
Cat. No.
BT11968
Source
Synonyms
AAG2, SNC6, HSPABP, FAM10A1, FAM10A4, HSPABP1, ST-13, Hsc70-interacting protein, Suppression of tumorigenicity protein 13, Putative tumor suppressor ST13, Protein FAM10A1, Progesterone receptor-associated p48 protein, Renal carcinoma antigen NY-REN-33, ST13, HIP, HOP, P48, PRO0786, FLJ27260, MGC129952.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Product Specs

Introduction
ST13 is an adaptor protein (co-chaperone) that mediates the association of HSP70 and HSP90 and appears in early receptor complexes. It plays a role in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. ST13 expression is downregulated in colorectal carcinoma tissue, signifying its potential as a tumor suppressor gene. By binding to both Hsp70 and Hsp90, ST13 acts as an adaptor, integrating their interactions. The expression of ST13 is reduced in colorectal cancer tissue compared to adjacent normal tissue. It is primarily found in colorectal epithelia and adenocarcinoma cells. ST13 enhances the efficiency of glucocorticoid receptor maturation within cells. Significantly decreased levels of ST13 gene expression are observed in primary tumors compared to adjacent mucosa.
Physical Appearance
Colorless and sterile filtered solution.
Formulation
The solution contains 1mg/ml of the product in a buffer of PBS at pH 7.4, with 10% Glycerol and 0.02% Sodium Azide.
Storage Procedures
Store at 4°C for up to 1 month. For longer storage periods, store at -20°C. Avoid repeated freeze-thaw cycles.
Stability / Shelf Life
The product is stable for 12 months at -20°C and 1 month at 4°C.
Applications
The ST13 antibody has been validated for ELISA and Western blot analysis to ensure its specificity and reactivity. However, optimal working dilutions should be determined empirically for each application. A starting dilution of 1:1000 is recommended.
Synonyms
AAG2, SNC6, HSPABP, FAM10A1, FAM10A4, HSPABP1, ST-13, Hsc70-interacting protein, Suppression of tumorigenicity protein 13, Putative tumor suppressor ST13, Protein FAM10A1, Progesterone receptor-associated p48 protein, Renal carcinoma antigen NY-REN-33, ST13, HIP, HOP, P48, PRO0786, FLJ27260, MGC129952.
Purification Method
ST13 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT5C6AT.
Immunogen
Anti-human ST13 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ST13 protein 1-369 amino acids purified from E. coli.
Ig Subclass
Mouse IgG2a heavy chain and k light chain.

Product Science Overview

Introduction

The HSP70 Interacting Protein Clone PAT5C6AT, Mouse Anti Human, is a monoclonal antibody used in various research applications. This antibody targets the Heat Shock Protein 70 (HSP70), a molecular chaperone that plays a crucial role in protein homeostasis by assisting in the folding, trafficking, and degradation of proteins.

Heat Shock Protein 70 (HSP70)

HSP70 is a highly conserved protein found in almost all living organisms, from bacteria to humans. It is a part of the heat shock protein family, which is upregulated in response to stress conditions such as heat, toxins, and infection. HSP70 helps in the proper folding of nascent proteins, refolding of misfolded proteins, and prevention of protein aggregation. It also assists in the degradation of damaged proteins by delivering them to the proteasome .

Monoclonal Antibodies

Monoclonal antibodies are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, or mimic the immune system’s attack on cells. They are designed to bind to specific targets, in this case, the HSP70 protein. The Clone PAT5C6AT is a mouse-derived monoclonal antibody that specifically targets human HSP70.

Applications

The HSP70 Interacting Protein Clone PAT5C6AT is used in various research applications, including:

  • Immunoprecipitation (IP): To isolate and study protein complexes.
  • Flow Cytometry (Flow Cyt): To analyze the expression of HSP70 on the cell surface.
  • Western Blotting (WB): To detect HSP70 in protein samples.
  • Immunohistochemistry (IHC-P): To visualize HSP70 in tissue sections.
  • Immunocytochemistry/Immunofluorescence (ICC/IF): To study the localization of HSP70 within cells .
Importance in Research

Understanding the interactions and functions of HSP70 is crucial for studying various diseases, including cancer, neurodegenerative disorders, and infections. HSP70’s role in protein homeostasis makes it a potential target for therapeutic interventions. The Clone PAT5C6AT antibody aids researchers in exploring these interactions and developing new treatments.

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