SSR2 Antibody

Signal Sequence Receptor Beta (SSR2) is a crucial component of the signal sequence receptor (SSR) complex, which is involved in the translocation of proteins across the endoplasmic reticulum (ER) membrane. This receptor is essential for the proper functioning of cellular processes, particularly in protein synthesis and folding.

The SSR complex consists of four subunits: alpha, beta, gamma, and delta. The beta subunit, encoded by the SSR2 gene, is a glycosylated protein that plays a pivotal role in binding calcium to the ER membrane. This binding is crucial for the retention of ER resident proteins and the regulation of protein translocation .

The SSR2 gene is located on chromosome bands 1q21-q23 in humans. It is associated with several diseases, including calcaneonavicular coalition and osteosarcoma . The gene’s expression is regulated through complex alternative polyadenylation, resulting in multiple transcript variants that encode different isoforms .

Mouse anti-human antibodies are commonly used in research to study human proteins. These antibodies are produced by immunizing mice with human proteins or peptides, leading to the generation of monoclonal antibodies that specifically recognize and bind to the target human protein. In the case of SSR2, mouse anti-human antibodies can be used to detect and study the beta subunit of the signal sequence receptor in various experimental settings .

The use of mouse anti-human SSR2 antibodies has several applications in biomedical research:

• Protein Localization: These antibodies can be used in immunofluorescence and immunohistochemistry to determine the localization of SSR2 within cells and tissues.
• Protein Interaction Studies: Co-immunoprecipitation assays can utilize these antibodies to study interactions between SSR2 and other proteins.
• Disease Research: By studying the expression and function of SSR2 in disease models, researchers can gain insights into its role in conditions like osteosarcoma and other related disorders.