sRAGE Human
Description
sRAGE Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 339 amino acids and having a molecular mass of 36.5 kDa.
The Human sRAGE is fused to a 14 a.a. His tag at N-Terminus.
The Human sRAGE is purified by proprietary chromatographic techniques.
Product Specs
Recombinant Human sRAGE, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 339 amino acids, resulting in a molecular weight of 36.5 kDa. This sRAGE protein features a 14-amino acid His tag fused at its N-terminus and is purified using proprietary chromatographic methods.
The protein solution, after sterile filtration (0.4 µm) and concentration (0.5 mg/ml), was lyophilized using a 30 mM acetate buffer at pH 4.
MRGSHHHHHH GMASAQNITA RIGEPLVLKC KGAPKKPPQR LEWKLNTGRT EAWKVLSPQG GGPWDSVARV LPNGSLFLPAV GIQDEGIFRCQ AMNRNGKETKS NYRVRVYQIP GKPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGKPL VPNEKGVSVK EQTRRHPETG LFTLQSELMV TPARGGDPRP TFSCSFSPGL PRHRALRTAP IQPRVWEPVPL EEVQLVVEPE GGAVAPGGTV TLTCEVPAQP SPQIHWMKDGVP LPLPPSPVLI LPEIGPQDQG TYSCVATHSS HGPQESRAVS ISIIEPGEEG PTAGEGFDKV REAEDSPQHM
Product Science Overview
The Advanced Glycosylation End Product-Specific Receptor (RAGE) is a transmembrane receptor of the immunoglobulin superfamily. It was first characterized in 1992 by Neeper et al. RAGE is known for its ability to bind advanced glycation end products (AGEs), which are proteins or lipids that become glycated after exposure to sugars .
RAGE is a 35 kilodalton receptor that plays a crucial role in various physiological and pathological processes. It is a multiligand receptor, meaning it can interact with multiple types of molecules, not just AGEs. These interactions are implicated in homeostasis, development, inflammation, and certain diseases such as diabetes and Alzheimer’s disease .
Human recombinant RAGE is used in research to study its role in various diseases and to develop potential therapeutic interventions. By understanding how RAGE functions and its interactions with AGEs, scientists aim to find ways to mitigate its harmful effects in diseases like diabetes and Alzheimer’s.
