SRA1 Human
Description
Product Specs
The Steroid receptor RNA activator 1 (SRA1) exists in both RNA transcript and protein forms, with the protein being constitutively expressed. SRA1 functions as a transcriptional coactivator of steroid receptors in a ligand-dependent manner through the steroid-binding domain (AF-2). It plays a role in enhancing cellular proliferation and differentiation and has been shown to induce apoptosis in vivo. SRA1 is implicated in tumorigenesis and participates in various cellular processes, including metabolism, adipogenesis, and chromatin organization.
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to freeze the product at -20°C.
To ensure optimal stability during long-term storage, adding a carrier protein (0.1% HSA or BSA) is advisable.
Repeated freezing and thawing of the product should be avoided.
Product Science Overview
Further research revealed that the SRA1 gene produces both a non-coding RNA and a protein-coding mRNA. The non-coding RNA component is part of a ribonucleoprotein complex that includes NCOA1, a nuclear receptor coactivator . The protein product, SRAP, acts as a transcriptional coactivator, enhancing steroid receptor-mediated transactivation through both ligand-dependent and ligand-independent mechanisms .
SRA1 and SRAP are involved in various biological processes, including:
- Transcriptional Regulation: SRA1 acts as a transcriptional coactivator for steroid receptors, enhancing their activity and influencing gene expression .
- Cell Proliferation and Differentiation: SRA1 promotes cellular proliferation and differentiation, playing a role in tissue development and homeostasis .
- Apoptosis: SRA1 has been shown to promote apoptosis, which is crucial for maintaining cellular balance and preventing uncontrolled cell growth .
- Metabolism and Adipogenesis: SRA1 is involved in metabolic regulation and adipogenesis, contributing to energy homeostasis and fat storage .
The expression of SRA1 and SRAP is associated with various diseases, including cancer. Increased levels of SRA1 have been linked to breast cancer, suggesting its role in tumorigenesis . Additionally, SRA1 is implicated in other conditions such as atrial standstill and laryngeal squamous cell carcinoma .
Given its involvement in critical biological processes and disease states, SRA1 is a target of interest for therapeutic interventions. Understanding the regulatory mechanisms of SRA1 and its interactions with other proteins could lead to novel treatments for cancer and other diseases.
