SORBS3 Human
Description
Product Specs
Product Science Overview
SORBS3 is widely expressed in various human tissues, including the heart, skeletal muscle, and adipose tissue. It plays a crucial role in cytoskeletal organization, cell adhesion, and migration. The presence of SH3 domains allows SORBS3 to bind other cytoplasmic molecules, contributing to its diverse functions .
The primary functions of SORBS3 include:
- Cytoskeletal Organization: SORBS3 interacts with actin filaments and other cytoskeletal proteins to maintain cell shape and structure.
- Cell Adhesion and Migration: It plays a role in cell adhesion and migration by interacting with integrins and other cell surface receptors.
- Signaling Pathways: SORBS3 is involved in various signaling pathways that regulate cell growth, differentiation, and survival.
- Gene Expression: It can influence gene expression by interacting with transcription factors and other nuclear proteins .
SORBS3 functions through its SH3 domains, which mediate interactions with other proteins. These interactions are essential for the formation of protein complexes that regulate cytoskeletal dynamics, cell adhesion, and signaling pathways. The protein also contains a sorbin homology (SoHo) domain, which interacts with lipid raft proteins, further contributing to its role in cellular signaling .
The expression and activity of SORBS3 are regulated by various mechanisms, including:
- Epigenetic Modifications: DNA methylation and histone modifications can influence the expression of the SORBS3 gene. For example, increased methylation of the SORBS3 promoter region has been associated with decreased gene expression in obesity .
- Post-Translational Modifications: Phosphorylation and ubiquitination of SORBS3 can modulate its activity and interactions with other proteins.
- Transcriptional Regulation: Transcription factors such as NF-κB and AP-1 can bind to the promoter region of the SORBS3 gene and regulate its transcription .
Alterations in SORBS3 expression and function have been implicated in various diseases, including obesity, diabetes, and cardiovascular diseases. For instance, changes in SORBS3 methylation and gene expression have been observed in skeletal muscle following weight loss induced by Roux-en-Y gastric bypass surgery . Additionally, SORBS3 has been linked to insulin sensitivity and glucose metabolism, making it a potential target for therapeutic interventions in metabolic disorders .
