SNAI2 Human

Snail Family Zinc Finger 2 Human Recombinant
Cat. No.
BT17604
Source
Escherichia Coli.
Synonyms
Snail Family Zinc Finger 2, SLUG, Protein Snail Homolog 2, WS2D, Slug Homolog, Zinc Finger Protein (Chicken), Slug (Chicken Homolog), Zinc Finger Protein, Neural Crest Transcription Factor SLUG, Neural Crest Transcription Factor Slug, Snail Homolog 2 (Drosophila), Zinc Finger Protein SNAI2, Snail Homolog 2, SLUGH1, SNAIL2, SLUGH, SNAI2.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

SNAI2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 291 amino acids (1-268 a.a) and having a molecular mass of 32.4kDa.
SNAI2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Snail Family Zinc Finger 2, also known as SNAI2, belongs to the snail C2H2-type zinc-finger protein family. This protein functions as a transcriptional repressor, binding to E-box motifs and likely repressing E-cadherin transcription in breast carcinoma. SNAI2 plays a role in epithelial-mesenchymal transitions and exhibits antiapoptotic activity.
Description
Recombinant human SNAI2, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 291 amino acids (residues 1-268) with a molecular weight of 32.4 kDa. The protein includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
Clear, sterile filtered solution.
Formulation
SNAI2 protein solution at a concentration of 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) with 10% glycerol.
Stability
For short-term storage (up to 2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 80.0% as determined by SDS-PAGE analysis.
Synonyms
Snail Family Zinc Finger 2, SLUG, Protein Snail Homolog 2, WS2D, Slug Homolog, Zinc Finger Protein (Chicken), Slug (Chicken Homolog), Zinc Finger Protein, Neural Crest Transcription Factor SLUG, Neural Crest Transcription Factor Slug, Snail Homolog 2 (Drosophila), Zinc Finger Protein SNAI2, Snail Homolog 2, SLUGH1, SNAIL2, SLUGH, SNAI2.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPRSFLV KKHFNASKKP NYSELDTHTV IISPYLYESY SMPVIPQPEI LSSGAYSPIT VWTTAAPFHA QLPNGLSPLS GYSSSLGRVS PPPPSDTSSK DHSGSESPIS DEEERLQSKL SDPHAIEAEK FQCNLCNKTY STFSGLAKHK QLHCDAQSRK SFSCKYCDKE YVSLGALKMH IRTHTLPCVC KICGKAFSRP WLLQGHIRTH TGEKPFSCPH CNRAFADRSN LRAHLQTHSD VKKYQCKNCS KTFSRMSLLH KHEESGCCVA H

Product Science Overview

Introduction

Snail Family Zinc Finger 2 (SNAI2), also known as SLUG, is a member of the Snail family of C2H2-type zinc finger transcription factors. These proteins play a crucial role in various biological processes, including embryonic development, cell differentiation, and cancer progression. SNAI2 is particularly known for its involvement in epithelial-mesenchymal transition (EMT), a process where epithelial cells lose their cell polarity and adhesion properties to become mesenchymal stem cells, which are highly migratory and invasive .

Structure and Function

SNAI2 is characterized by the presence of zinc finger domains, which enable it to bind to specific DNA sequences known as E-box motifs. This binding allows SNAI2 to function as a transcriptional repressor, regulating the expression of target genes. One of the primary targets of SNAI2 is E-cadherin, a protein essential for cell-cell adhesion in epithelial tissues. By repressing E-cadherin transcription, SNAI2 promotes EMT, contributing to cancer metastasis and tumor progression .

Biological Significance

The role of SNAI2 in EMT and its antiapoptotic activity make it a critical factor in cancer biology. EMT is not only essential for normal embryonic development but also plays a significant role in the progression of various cancers, including breast carcinoma. The ability of SNAI2 to induce EMT and inhibit apoptosis provides cancer cells with the properties needed for invasion, migration, and resistance to cell death .

Recombinant SNAI2

Human recombinant SNAI2 is produced using recombinant DNA technology, which involves inserting the SNAI2 gene into an expression vector and introducing it into a host cell, typically bacteria or yeast. The host cells then produce the SNAI2 protein, which can be purified for research and therapeutic purposes. Recombinant SNAI2 is used in various studies to understand its function, regulation, and potential as a therapeutic target in cancer treatment .

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