SLA2 Human
Src-Like-Adaptor 2 Human Recombinant
Cat. No.
BT16791
Source
Escherichia Coli.
Synonyms
Src-like-adapter 2, Modulator of antigen receptor signaling, MARS, Src-like adapter protein 2, SLAP-2, SLA2, C20orf156, SLAP2, Src-like-adapter 2 isoform a, Src-like-adaptor 2, C20orf156, MARS, SLAP-2, SLAP2.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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In Stock 
Description
SLA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 284 amino acids (1-261 a.a.) and having a molecular mass of 31kDa.
SLA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SLA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Src-Like-Adaptor 2, also known as SLA2, belongs to the SLAP family of adapter proteins. It plays a crucial role as a receptor-proximal molecule in suppressing T and B cell-mediated immune responses. SLA2 achieves this by inhibiting the mobilization of calcium ions triggered by antigen receptors. Furthermore, SLA2 interacts with the Cas-Br-M (murine) ecotropic retroviral transforming sequence c.
Description
Recombinant SLA2 Human, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 284 amino acids (specifically, amino acids 1 to 261) with a molecular weight of 31 kDa. This protein is expressed with a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
The product is provided as a sterile, filtered solution that is colorless.
Formulation
The SLA2 protein solution is supplied at a concentration of 0.5 mg/ml and is formulated in a buffer containing 20 mM Tris-HCl (pH 8.0), 10% glycerol, and 0.4 M Urea.
Stability
For short-term storage (up to 2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to store the product frozen at -20°C. To further enhance long-term stability during frozen storage, consider adding a carrier protein such as HSA or BSA to a final concentration of 0.1%. Repeated freezing and thawing of the product should be avoided.
Purity
The purity of the SLA2 protein is determined to be greater than 80.0% by SDS-PAGE analysis.
Synonyms
Src-like-adapter 2, Modulator of antigen receptor signaling, MARS, Src-like adapter protein 2, SLAP-2, SLA2, C20orf156, SLAP2, Src-like-adapter 2 isoform a, Src-like-adaptor 2, C20orf156, MARS, SLAP-2, SLAP2.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGSLPSR RKSLPSPSLS SSVQGQGPVT MEAERSKATA VALGSFPAGG PAELSLRLGE PLTIVSEDGD WWTVLSEVSG REYNIPSVHV AKVSHGWLYE GLSREKAEEL LLLPGNPGGA FLIRESQTRR GSYSLSVRLS RPASWDRIRH YRIHCLDNGW LYISPRLTFP SLQALVDHYS ELADDICCLL KEPCVLQRAG PLPGKDIPLP VTVQRTPLNW KELDSSLLFS EAATGEESLL SEGLRESLSF YISLNDEAVS LDDA.
Product Science Overview
Historical Background
Structure and Function
The SLA2 protein consists of several domains that facilitate its function as an adapter protein. These domains include:
- SH2 domain: This domain allows SLA2 to bind to phosphorylated tyrosine residues on other proteins.
- SH3 domain: This domain mediates interactions with proline-rich regions of other proteins.
SLA2 acts as a significant receptor-proximal protein, meaning it operates close to the cell surface receptors. It plays a pivotal role in inhibiting antigen receptor-induced calcium mobilization, which is essential for the activation and function of T and B cells .
Recombinant Human SLA2
Recombinant human SLA2 is a denatured protein with an N-terminal His-tag, corresponding to the amino acids 1-261 of the human SLA2 protein. It is expressed in Escherichia coli and is used in various research applications . The recombinant protein is typically stored in a buffer containing Tris-HCl, glycerol, and urea to maintain its stability .
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