SIX1 Human

The SIX1 gene is a protein-coding gene associated with several developmental processes. It encodes the SIX1 protein, which plays a significant role in the development of various tissues and organs, including the kidney, brain, and nose . The SIX1 protein is composed of 284 amino acids and has a molecular weight of approximately 34.7 kDa .

SIX1 is fundamentally involved in the development of cell populations that contribute to the formation of key features of the human body. It has been shown to play roles in vertebrate and insect development and is implicated in maintaining the differentiated state of tissues . The protein is also involved in the development of at least forty vertebrates, though the true number is likely much greater .

SIX1 interacts with several other proteins, including EYA1, DACH, GRO, and MDFI . These interactions are crucial for its role in various developmental pathways, such as kidney development and nervous system development . Mutations in the SIX1 gene can lead to serious consequences, including elevated levels of SIX genes in certain types of cancer and tumorigenesis .

Recombinant human SIX1 protein, fused to a His-tag at the N-terminus, is expressed in E. coli. This recombinant protein is used for research purposes to study the function and interactions of SIX1 in various biological processes . The protein is typically stored at 4°C for short-term use and at -20°C for long-term storage to avoid freeze-thaw cycles .

Diseases associated with SIX1 include Branchiootic Syndrome 3 and Autosomal Dominant Deafness 23 . The study of recombinant SIX1 protein helps in understanding these diseases and developing potential therapeutic strategies.