SIVA1 Human
Escherichia Coli.
Apoptosis regulatory protein Siva isoform 1, Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP, SIVA, SIVA1, Siva-1, Siva-2
Greater than 85.0% as determined by SDS-PAGE.
Description
SIVA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (1-175 a.a.) and having a molecular mass of 21.1 kDa.
SIVA1 is fused to a 23 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Apoptosis regulatory protein Siva isoform 1, Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP, SIVA, SIVA1, Siva-1, Siva-2
Escherichia Coli.
MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHL PESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET
Product Science Overview
SIVA1, also known as SIVA1 apoptosis inducing factor, is a protein encoded by the SIVA1 gene in humans. This protein plays a crucial role in regulating cell cycle progression, cell proliferation, and apoptosis. The recombinant form of SIVA1 is often used in research to study its functions and interactions in various cellular processes.
The SIVA1 gene is located on chromosome 14 and encodes a protein that is part of the tumor necrosis factor receptor (TNFR) superfamily. The protein has several isoforms, with SIVA1 being the most studied. The N-terminus of the SIVA1 protein binds to the cytoplasmic tail of the CD27 antigen, a member of the TNFR superfamily .
SIVA1 is an E3 ubiquitin ligase, which means it plays a role in tagging proteins for degradation by the proteasome. This function is essential for maintaining cellular homeostasis and regulating various cellular processes. Some of the key functions of SIVA1 include:
- Regulation of Apoptosis: SIVA1 induces CD27-mediated apoptosis, which is a form of programmed cell death. This process is crucial for eliminating damaged or unwanted cells from the body .
- Inhibition of Anti-Apoptotic Activity: SIVA1 inhibits the anti-apoptotic activity of BCL2L1 isoform Bcl-x (L), promoting cell death in response to specific signals .
- Inhibition of NF-kappa-B Activation: SIVA1 inhibits the activation of NF-kappa-B, a transcription factor involved in immune response and cell survival .
- Promotion of T-cell Receptor-Mediated Apoptosis: SIVA1 promotes apoptosis in T-cells, which is essential for maintaining immune system balance .
SIVA1 is expressed in various tissues, including lymphoid tissue, bone marrow, testis, and skeletal muscle. It is involved in multiple cellular pathways, such as the 4-1BB pathway and the TNFR1 pathway . The protein is localized in different cellular compartments, including the cytoplasm and nucleus, where it interacts with other proteins to execute its functions .
The recombinant form of SIVA1 is widely used in research to study its role in apoptosis and other cellular processes. Understanding the functions and mechanisms of SIVA1 can provide insights into various diseases, including cancer and autoimmune disorders. Researchers are also exploring the potential of targeting SIVA1 for therapeutic purposes, such as developing drugs that modulate its activity to treat specific conditions.
