Sincalide
Sincalide
Cat. No.
BT17315
Source
Synonyms
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 99.0% as determined by RP-HPLC.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Sincalide also called CCK-8 has a molecular formula of C49H62N10O16S3 , H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 having an Mw of 1143.29 Dalton.
Product Specs
Introduction
Sincalide, the C-terminal octapeptide of cholecystokinin (CCK), acts on gallbladder wall receptors, inducing contraction. CCK, initially isolated from porcine intestinal mucosa, is a linear 33-amino acid peptide with a sulfated tyrosine crucial for its biological activity. Found in the mammalian digestive tract and central nervous system, it stimulates pancreatic exocrine secretion, gallbladder contraction, and intestinal motility. It may also function as a neurotransmitter/neuromodulator in the central nervous system.
Description
Sincalide (CCK-8), with a molecular formula of C49H62N10O16S3 and a molecular weight of 1143.29 Daltons, has the structure H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2.
Physical Appearance
White, sterile, lyophilized powder.
Formulation
Sincalide is lyophilized from a 1 mg/mL solution without additives.
Solubility
Reconstitute lyophilized Sincalide in sterile 18 MΩ-cm H2O to a concentration of 0.5 mg/mL. This solution can be further diluted with other aqueous solutions.
Stability
Lyophilized Sincalide remains stable at room temperature for 3 weeks but should be stored desiccated below -18°C. Reconstituted CCK-8 is stable at 4°C for 2-7 days. For long-term storage, freeze at -18°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid freeze-thaw cycles.
Purity
Purity exceeds 99.0% as determined by RP-HPLC.
Product Science Overview
Chemical Structure and Properties
Mechanism of Action
Clinical Uses
Sincalide is used in various diagnostic tests, including:
- Gallbladder Function Tests: It helps in assessing gallbladder contraction and bile release, which can be evaluated using imaging techniques like cholecystography or ultrasonography .
- Pancreatic Function Tests: When used in combination with secretin, sincalide stimulates the pancreas to secrete enzymes and bicarbonate, which can be analyzed to assess pancreatic function .
- Intestinal Transit Studies: Sincalide accelerates the transit of a barium meal through the small intestine, reducing the time and extent of radiation exposure during fluoroscopy and x-ray examinations .
Administration and Dosage
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