SH3GL3 Human
SH3-Domain GRB2-Like 3 Human Recombinant
Cat. No.
BT16053
Source
Escherichia Coli.
Synonyms
SH3-Domain GRB2-Like 3, SH3 Domain-Containing GRB2-Like Protein 3, SH3 Domain Protein 2C, Endophilin-3, EEN-B2, SH3D2C, CNSA3, Endophilin-A3, HsT19371, SH3P13, EEN-2B-L3.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
SH3GL3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-347 a.a) and having a molecular mass of 41.7kDa. SH3GL3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
SH3-Domain GRB2-Like 3, also known as SH3GL3, is a member of the endophilin family. This protein contains one BAR domain and one SH3 domain and plays a role in endocytosis. SH3GL3 is responsible for encoding proteins that interact with membranes and contribute to their curvature.
Description
Recombinant human SH3GL3 protein expressed in E. coli. This product is a single, non-glycosylated polypeptide chain consisting of 370 amino acids (residues 1-347) with a molecular weight of 41.7 kDa. The protein includes an N-terminal 23 amino acid His-tag and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear solution that has been sterilized by filtration.
Formulation
This solution contains SH3GL3 protein at a concentration of 1 mg/ml. It is formulated in a buffer consisting of PBS at pH 7.4, 10% glycerol, and 1mM DTT.
Stability
For short-term storage (up to 2-4 weeks), keep at 4°C. For longer storage, freeze at -20°C. Adding a carrier protein such as 0.1% HSA or BSA is recommended for long-term storage. Avoid repeated freezing and thawing.
Purity
Purity is determined to be greater than 90.0% using SDS-PAGE analysis.
Synonyms
SH3-Domain GRB2-Like 3, SH3 Domain-Containing GRB2-Like Protein 3, SH3 Domain Protein 2C, Endophilin-3, EEN-B2, SH3D2C, CNSA3, Endophilin-A3, HsT19371, SH3P13, EEN-2B-L3.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSVAGLK KQFHKASQLF SEKISGAEGT KLDDEFLDME RKIDVTNKVV AEILSKTTEY LQPNPAYRAK LGMLNTVSKI RGQVKTTGYP QTEGLLGDCM LKYGKELGED STFGNALIEV GESMKLMAEV KDSLDINVKQ TFIDPLQLLQ DKDLKEIGHH LKKLEGRRLD YDYKKKRVGK IPDEEVRQAV EKFEESKELA ERSMFNFLEN DVEQVSQLAV FIEAALDYHR QSTEILQELQ SKLQMRISAA SSVPRREYKP RPVKRSSSEL NGVSTTSVVK TTGSNIPMDQ PCCRGLYDFE PENQGELGFK EGDIITLTNQ IDENWYEGMI HGESGFFPIN YVEVIVPLPQ.
Product Science Overview
Evolutionary Conservation and Expression
Function and Molecular Interactions
Although the precise function of SH3BGRL3 is not fully understood, it has been implicated in several cellular processes. Notably, SH3BGRL3 has been found to interact with myosin 1c (Myo1c) in a calcium-dependent manner . This interaction is crucial for the regulation of cytoskeletal dynamics and cell migration . SH3BGRL3 does not directly bind to ErbB2, a member of the EGFR family, but it co-localizes with Myo1c and ErbB2 at the plasma membrane .
Role in Cancer
Research and Clinical Implications
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
