SGTA Human

Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha Human Recombinant
Cat. No.
BT15972
Source
Escherichia Coli.
Synonyms
alphaSGT, hSGT, SGT, Vpu-binding protein, UBP, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, SGT1.
Appearance
Sterile filtered colorless solution.
Purity
Greater than 95% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

SGTA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 321 amino acids (1-313 a.a.) and having a molecular mass of 35.1 kDa. SGTA protein is fused to a 8 amino acid His-Tag at C-terminus and purified by standard chromatography.

Product Specs

Introduction
SGTA is a ubiquitous protein with three TPR protein-protein interaction domains. It acts as a component of the androgen receptor (AR) chaperone-cochaperone complex, functioning as a cochaperone in androgen signaling. SGTA directly binds to and mediates the ATPase activity of HSC70 and HSP70. The SGTA gene encodes a protein that interacts with the main nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein. Additionally, SGTA interacts with HIV-1 Vpu and Gag, SARS-CoV accessory protein 7a, DNAJC5, and DNAJC5B. Its ubiquitous expression suggests a housekeeping function. Involved in apoptosis and androgen signaling, SGTA is implicated in polycystic ovary syndrome, a disorder characterized by androgen excess, obesity, and menstrual irregularities.
Description
Recombinant Human SGTA, produced in E. coli, is a single, non-glycosylated polypeptide chain containing 321 amino acids (1-313 a.a.) with a molecular weight of 35.1 kDa. The protein is fused to an 8 amino acid His-tag at the C-terminus and purified using standard chromatography techniques.
Physical Appearance
A clear, colorless solution that has been sterilized by filtration.
Formulation
SGTA Human solution is supplied in a buffer containing 20mM Tris-HCl (pH 8.0), 1mM DTT, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), store at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity is determined to be greater than 95% by SDS-PAGE analysis.
Synonyms
alphaSGT, hSGT, SGT, Vpu-binding protein, UBP, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, SGT1.
Source
Escherichia Coli.
Amino Acid Sequence

MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR SRTPSASNDD QQELEHHHHH H.

Product Science Overview

Introduction

Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) is a co-chaperone protein that plays a crucial role in the quality control of secretory and membrane proteins mislocalized to the cytosol . It is involved in the biogenesis of tail-anchored (TA) membrane proteins and has established roles in various cellular processes . SGTA is ubiquitously expressed in various tissues, suggesting it may serve a housekeeping function .

Structure and Function

SGTA contains multiple tetratricopeptide repeat (TPR) motifs, which are known for mediating protein-protein interactions . These motifs enable SGTA to interact with misfolded and hydrophobic patches-containing client proteins in the cytosol, mediating their targeting to the endoplasmic reticulum (ER) or regulating their sorting to the proteasome when targeting fails . SGTA functions upstream of the BAG6 complex and ASNA1, binding more rapidly to the transmembrane domain of newly synthesized proteins .

Role in Disease

SGTA has been implicated in various diseases, including polycystic ovary syndrome (PCOS) and non-small cell lung cancer (NSCLC). In PCOS, SGTA is a putative member of the androgen receptor–chaperone–co-chaperone complex and may play a role in androgen signaling as a co-chaperone . Polymorphisms in the SGTA gene have been associated with increased risk of PCOS and insulin resistance . In NSCLC, SGTA is highly expressed and significantly correlated with histological differentiation, clinical stage, and Ki-67, making it an independent prognostic factor for patient survival .

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