SERPINE1 Antibody
Serpin Family E Member 1, Endothelial Plasminogen Activator Inhibitor, Serpin E1, PLANH1, PAI-1, PAI1, PAI, Plasminogen Activator Inhibitor Type I, Plasminogen Activator Inhibitor 1, SERPINE1.
Description
Product Specs
Serpin Family E Member 1, Endothelial Plasminogen Activator Inhibitor, Serpin E1, PLANH1, PAI-1, PAI1, PAI, Plasminogen Activator Inhibitor Type I, Plasminogen Activator Inhibitor 1, SERPINE1.
SERPINE1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
PAT1C5AT.
Anti-human SERPINE1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SERPINE1 amino acids 24-402 purified from E. coli.
Mouse IgG1 heavy chain and k light chain.
Product Science Overview
Plasminogen Activator Inhibitor-1 (PAI-1) is a significant protein in the regulation of fibrinolysis, the process that prevents blood clots from growing and becoming problematic. PAI-1 is a member of the serine protease inhibitor (SERPIN) family and is encoded by the SERPINE1 gene in humans . It functions as the principal inhibitor of tissue-type plasminogen activator (tPA) and urokinase (uPA), which are crucial for the activation of plasminogen and subsequent fibrinolysis .
PAI-1’s primary role is to inhibit the activity of tPA and uPA, thereby regulating the conversion of plasminogen to plasmin . Plasmin is an enzyme that degrades fibrin clots, and by inhibiting its formation, PAI-1 plays a crucial role in maintaining the balance between clot formation and dissolution . Elevated levels of PAI-1 are associated with an increased risk of thrombosis and atherosclerosis .
PAI-1 is implicated in various pathological conditions, including cancer, fibrosis, and cardiovascular diseases . In cancer, PAI-1 has a paradoxical role; while it is a protease inhibitor, it is often associated with poor outcomes in cancer patients . Studies have shown that PAI-1 can exert a protective effect against tumor cell apoptosis, thereby promoting tumor growth and survival . In fibrotic diseases, elevated PAI-1 levels contribute to excessive fibrin deposition, leading to organ fibrosis .
Mouse anti-human PAI-1 antibodies are used in research to study the function and regulation of PAI-1 in various biological processes and diseases. These antibodies are crucial tools for investigating the role of PAI-1 in human health and disease, providing insights into potential therapeutic targets for conditions associated with abnormal PAI-1 activity .
