SERPINB2 Human, His

SERPINB2 is a protein-coding gene located on chromosome 18 in humans . The protein encoded by this gene is involved in inhibiting urokinase-type plasminogen activator (uPA), which plays a crucial role in fibrinolysis, a process that prevents blood clots from growing and becoming problematic .

The recombinant form of this protein, tagged with a His (histidine) tag, is often used in research to facilitate purification and detection. The His tag is a string of histidine residues added to the protein, which binds strongly to nickel or cobalt ions, allowing for easy isolation using metal affinity chromatography.

SERPINB2 functions by inhibiting serine-type endopeptidase activity, which is essential in regulating various physiological processes, including inflammation, immune response, and tissue remodeling . It acts as a suicide substrate inhibitor, meaning it forms a stable complex with the target protease, leading to its inactivation .

SERPINB2 has been associated with several diseases, including gingivitis and pre-eclampsia . Its role in inhibiting uPA makes it significant in controlling processes like cell migration and tissue invasion, which are critical in cancer metastasis and wound healing .

The human recombinant form of SERPINB2 with a His tag is widely used in research to study its function and interactions. It is particularly useful in investigating its role in various signaling pathways, such as the Interleukin-12 family signaling and cytokine signaling in the immune system .