SERPINA9 Mouse
Description
SERPINA9 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Serpin Peptidase Inhibitors are a diverse group of proteins that primarily function as inhibitors of serine proteases. The term “serpin” is derived from their role as serine protease inhibitors. These proteins are found across all kingdoms of life and play crucial roles in various physiological processes, including inflammation, immune response, blood coagulation, and cellular homeostasis .
The serpin superfamily is divided into several clades based on sequence similarity. In humans, there are 36 protein-coding serpin genes, while mice have 60 functional serpin genes . The clades are labeled A through P, with clade A being one of the most studied due to its involvement in numerous physiological and pathological processes .
Serpin Peptidase Inhibitor, Clade A, Member 1 (SERPINA1) is a well-known member of this family. It is also known as alpha-1-antitrypsin (AAT) and is a major plasma serine protease inhibitor. SERPINA1 primarily inhibits elastase but also has moderate affinity for other proteases such as trypsin, chymotrypsin, and thrombin . The recombinant form of this protein, derived from mouse models, is used extensively in research to study its function and therapeutic potential.
Serpins function through a unique mechanism known as the “suicide substrate” mechanism. They present a reactive center loop (RCL) that acts as a bait for the target protease. Upon cleavage of the RCL by the protease, the serpin undergoes a significant conformational change, trapping the protease in a covalent complex and thereby inhibiting its activity . This irreversible inhibition is crucial for regulating proteolytic activity in various biological processes.
Recombinant forms of serpin peptidase inhibitors, such as the mouse recombinant SERPINA1, are invaluable tools in biomedical research. They are used to study the molecular mechanisms of protease inhibition, the role of serpins in disease, and their potential as therapeutic agents. For instance, SERPINA1 is being investigated for its role in conditions like chronic obstructive pulmonary disease (COPD) and liver diseases, where its deficiency or dysfunction leads to pathological proteolytic activity .
