SERPINA7 Human
Human serum.
Sterile Filtered White lyophilized (freeze-dried) powder.
Greater than 98.0%.
Description
Human Serpin Peptidase Inhibitor, Clade A Member 7 Protein produced in Human plasma having a molecular mass of approximately 55kD.
Product Specs
Thyroxine binding globulin, also called SERPINA7, is a protein produced by the liver that helps transport thyroid hormones in the blood. Changes in SERPINA7 levels can occur in various health conditions. Measuring SERPINA7 is important for understanding thyroid function by determining the levels of free T3 and T4 hormones. It binds to and carries the majority of T3 and T4 in the bloodstream. Typically, about 25% of Thyroxine binding globulin has a T3 or T4 hormone bound to it.
This is a purified protein, called SERPINA7, that is naturally found in human blood. It is approximately 55 kilodaltons in size.
It appears as a white powder that has been freeze-dried and sterilized through filtration.
The protein powder was freeze-dried from a solution containing 20mM NH4HCO3 and filtered through a 0.2 micrometer filter.
To reconstitute the freeze-dried SERPINA7 Human, dissolve it in a phosphate buffer solution containing 0.15M NaCl.
While SERPINA7 Human remains stable at room temperature for up to 3 weeks, it is recommended to store it between 2-8 degrees Celsius for long-term preservation.
The purity of this product is greater than 98%.
The donor of the starting material for this product has undergone testing and been confirmed negative for various viral infections including HIV-1, HIV-2, HCV, HBSAG, Parvovirus B19, Syphilis. Additional PCR testing confirms the absence of HIV, HBV, and HCV.
Human serum.
Product Science Overview
Serpin Peptidase Inhibitor, Clade A Member 7 (SERPINA7), also known as Thyroxine-Binding Globulin (TBG), is a protein encoded by the SERPINA7 gene. This protein is a member of the serpin superfamily, which is known for its role in inhibiting serine proteases. However, unlike many other serpins, SERPINA7 primarily functions as a hormone-binding protein rather than a protease inhibitor .
The primary function of SERPINA7 is to bind and transport thyroid hormones, including thyroxine (T4) and triiodothyronine (T3), in the bloodstream. By binding to these hormones, SERPINA7 regulates their availability and activity, ensuring that they are delivered to tissues in a controlled manner. This binding also protects the hormones from degradation and excretion .
Mutations in the SERPINA7 gene can lead to various thyroid hormone transport disorders. For example, Thyroxine-Binding Globulin Deficiency is a condition characterized by reduced levels of TBG, leading to altered thyroid hormone levels in the blood. Conversely, Thyroxine-Binding Globulin Excess results in elevated TBG levels, which can also affect thyroid hormone homeostasis .
