SEMAX

Semax is composed of the amino acid sequence Met-Glu-His-Phe-Pro-Gly-Pro, which corresponds to the ACTH (4-10) fragment. This sequence is modified to enhance its stability and biological activity . The chemical formula of Semax is C37H51N9O10S, and it has a molar mass of 813.93 g/mol .

The exact mechanism of action of Semax is not fully understood. However, it is believed to interact with melanocortin receptors and inhibit enkephalinase enzymes . These interactions may contribute to its neuroprotective and cognitive-enhancing effects. Additionally, Semax has been shown to increase the levels of brain-derived neurotrophic factor (BDNF), which plays a crucial role in neuroplasticity and recovery after brain injuries .

Semax has been extensively studied and used in Russia for various medical conditions, including:

• Stroke and Transient Ischemic Attack (TIA): Semax is used to improve recovery and rehabilitation after stroke and TIA .
• Memory and Cognitive Disorders: It has been shown to enhance attention, short-term memory, and cognitive functions .
• Peptic Ulcers: Semax is used to promote healing and reduce symptoms of peptic ulcers .
• Optic Nerve Disease: It is used to treat optic nerve diseases and improve vision .
• Immune System Boost: Semax has immunomodulatory effects and is used to boost the immune system .

Several clinical trials have been conducted to evaluate the efficacy and safety of Semax. In a 1996 study, Semax improved attention and short-term memory in healthy subjects performing 8-hour work shifts . Another study in 2018 involving patients recovering from ischemic stroke reported increased levels of BDNF and improved rehabilitation outcomes .

Semax is approved for medical use in Russia and is listed on the Russian List of Vital & Essential Drugs . However, it has not been evaluated or approved by regulatory authorities in most other countries, including the United States . Despite this, Semax is widely available through online vendors and is used as a nootropic supplement .