Semaglutide
Greater than 97.0% as determined by analysis by RP-HPLC.
Description
Semaglutide Synthetic is a single, non-glycosylated polypeptide chain containing 31 amino acids, having a molecular mass of 4113 Dalton and a Molecular formula of C187H291N45O59.
Product Specs
H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH.
Product Science Overview
Semaglutide is a peptide composed of 31 amino acids. Its chemical formula is C187H291N45O59, and it has a molar mass of approximately 4113.64 g/mol . The structure of semaglutide includes modifications that enhance its stability and prolong its action in the body. These modifications include the addition of a side chain that allows it to bind to albumin, a protein in the blood, which helps to extend its half-life.
Semaglutide works by binding to and activating the GLP-1 receptor. This receptor is found on the surface of pancreatic beta cells, which are responsible for producing insulin. When semaglutide activates the GLP-1 receptor, it stimulates the release of insulin in response to meals, helping to lower blood sugar levels. Additionally, semaglutide reduces the release of glucagon, a hormone that raises blood sugar levels, and slows down gastric emptying, which helps to reduce appetite and promote weight loss .
Semaglutide is marketed under several brand names, including Ozempic, Wegovy, and Rybelsus. Each brand has specific indications:
- Ozempic: Used for the treatment of type 2 diabetes to improve glycemic control and reduce the risk of major cardiovascular events such as heart attack and stroke. It is administered as a subcutaneous injection once a week .
- Wegovy: Approved for long-term weight management in adults with obesity or overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. It is also administered as a subcutaneous injection once a week .
- Rybelsus: An oral form of semaglutide used to improve glycemic control in adults with type 2 diabetes. It is taken once daily .
Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to decrease over time as the body adjusts to the medication. However, there are some serious side effects to be aware of, such as pancreatitis, kidney problems, and allergic reactions. Semaglutide is not recommended for use in individuals with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 .
