SEC22B Human
Description
SEC22B is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
SEC22B is a SNARE protein involved in the targeting and fusion of ER-derived transport vesicles with the Golgi complex, as well as Golgi-derived retrograde transport vesicles with the ER . This protein is essential for maintaining the proper function and organization of the secretory pathway, which is critical for cellular homeostasis and protein trafficking .
- ER-Golgi Transport: SEC22B is involved in the transport of proteins from the ER to the Golgi apparatus .
- Protein Transport: It plays a role in the general transport of proteins within the cell .
- Vesicle Trafficking: SEC22B is crucial for the formation and fusion of vesicles that transport proteins between cellular compartments .
Recombinant SEC22B refers to the protein produced through recombinant DNA technology, where the SEC22B gene is cloned and expressed in a host organism, such as bacteria or yeast. This allows for the production of large quantities of the protein for research and therapeutic purposes.
Mutations or dysregulation of the SEC22B gene can be associated with various diseases, including Pontiac Fever and Immunodeficiency 73C with Defective Neutrophil Chemotaxis and Hypogammaglobulinemia . Understanding the function and regulation of SEC22B is important for developing potential therapeutic strategies for these conditions.
Recombinant SEC22B is used in various research applications, including:
- Studying Vesicle Trafficking: Researchers use recombinant SEC22B to study the mechanisms of vesicle formation, targeting, and fusion.
- Protein-Protein Interactions: It is used to investigate interactions with other SNARE proteins and components of the vesicle trafficking machinery.
- Drug Development: Recombinant SEC22B can be used in high-throughput screening assays to identify potential therapeutic compounds that modulate its function.
