SEC13 Human
Protein SEC13 homolog, SEC13-like protein 1, SEC13-related protein, SEC13, D3S1231E, SEC13L1, SEC13R, npp-20.
Description
SEC13 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 342 amino acids (1-322 a.a.) and having a molecular mass of 37.7kDa.
The SEC13 is purified by proprietary chromatographic techniques.
Product Specs
Protein SEC13 homolog, SEC13-like protein 1, SEC13-related protein, SEC13, D3S1231E, SEC13L1, SEC13R, npp-20.
MGSSHHHHHH SSGLVPRGSH MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWREEN GTWEKSHEHA GHDSSVNSVC WAPHDYGLIL ACGSSDGAIS LLTYTGEGQW EVKKINNAHT IGCNAVSWAP
AVVPGSLIDH PSGQKPNYIK RFASGGCDNL IKLWKEEEDG QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV FIWTCDDASS NTWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI SDVNKGQGSV SASVTEGQQN EQ.
Product Science Overview
SEC13 is a protein encoded by the SEC13 gene in humans. It belongs to the SEC13 family of WD-repeat proteins and is a crucial component of the endoplasmic reticulum and the nuclear pore complex . The protein has significant similarity to the yeast SEC13 protein, which is essential for vesicle biogenesis from the endoplasmic reticulum during protein transport .
SEC13 is involved in the formation of vesicles in the COPII complex, which includes other proteins such as Sec23p, Sec24p, Sar1p, and Sec31 . The COPII vesicle budding complex was initially described in the yeast system and was shown to provide coat proteins in the early secretory pathway . In humans, SEC13 plays a similar role in vesicle formation and transport.
The SEC13 protein is ubiquitously expressed and participates in various cellular processes, including mRNA transport, protein transport, and intracellular protein transport . It is also involved in the positive regulation of TOR signaling, sister chromatid cohesion, and the regulation of glycolytic processes . Additionally, SEC13 is a structural component of the nuclear pore complex, contributing to the transport of molecules between the nucleus and the cytoplasm .
Recombinant SEC13 is produced using recombinant DNA technology, which involves inserting the SEC13 gene into an expression system to produce the protein in vitro. This recombinant protein can be used in various research applications, including studies on vesicle formation, protein transport, and nuclear pore complex function.
