SCGN Human
Description
Product Specs
Product Science Overview
Secretagogin was initially identified in the pancreas, where it was found to be involved in hormone secretion . Subsequent research revealed its presence in other tissues, particularly in the nervous system, where it exhibits characteristic expression patterns, often forming cell clusters . The protein’s regional expression and subcellular localization suggest that it has a central role in hormone secretion and possibly other cellular functions .
Secretagogin is characterized by its EF-hand motifs, which are helix-loop-helix structural domains capable of binding calcium ions . These motifs enable secretagogin to participate in calcium signaling pathways, which are essential for various cellular activities such as exocytosis, endocytosis, and gene expression . The protein’s ability to bind calcium with high affinity makes it a critical player in translating calcium signals into specific cellular responses .
In the nervous system, secretagogin is expressed in subsets of developing and adult neurons . Its expression patterns have been used to distinguish different neuronal cell populations, especially before the advent of advanced techniques like single-cell transcriptomics . The identification of numerous interacting proteins through modern proteomics has expanded our understanding of secretagogin’s role, suggesting it has a more complex function in neuronal cells than previously thought .
Recombinant secretagogin is produced using recombinant DNA technology, which involves inserting the gene encoding secretagogin into a host organism, such as bacteria or yeast, to produce the protein in large quantities. This recombinant form is used in various research applications to study the protein’s function, interactions, and potential therapeutic uses .
Research on secretagogin has provided insights into its role in calcium signaling and its potential implications in health and disease . Studies have shown that secretagogin is involved in processes such as neurotransmission, hormonal actions, and apoptosis . Understanding the protein’s function and interactions could lead to new therapeutic strategies for diseases related to calcium signaling dysregulation .
