JNK2/SAPK1 Human
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Description
SAPK1/JNK2 is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
JNK2, also known as c-Jun N-terminal kinase 2, is a member of the stress-activated protein kinase (SAPK) family. It is encoded by the MAPK9 gene in humans and plays a crucial role in various cellular processes, including proliferation, differentiation, and apoptosis. JNK2 is part of the larger mitogen-activated protein kinase (MAPK) pathway, which is involved in transmitting extracellular signals to the cell nucleus.
JNK2 is a serine/threonine kinase that is activated by dual phosphorylation on threonine and tyrosine residues. This activation is typically mediated by upstream kinases such as MKK4 (SEK1) and MKK7. Upon activation, JNK2 translocates to the nucleus, where it phosphorylates various transcription factors, including c-Jun, ATF-2, and Elk-1 .
JNK2 is involved in several physiological processes:
- Cell Proliferation and Differentiation: JNK2 regulates the expression of genes involved in cell cycle progression and differentiation.
- Apoptosis: JNK2 activation can lead to apoptosis in response to various stress signals, including UV radiation and oxidative stress .
- Immune Response: JNK2 plays a role in the immune response by regulating the production of cytokines and other immune mediators .
Recombinant JNK2 is produced using recombinant DNA technology, where the human MAPK9 gene is cloned into an expression vector and introduced into a host cell, such as E. coli or mammalian cells. The expressed protein is then purified for use in research and therapeutic applications. Recombinant JNK2 is commonly used in studies to understand its role in cellular signaling and to develop potential therapeutic interventions for diseases where JNK2 is implicated .
Research on JNK2 has provided insights into its role in various diseases, including cancer, neurodegenerative disorders, and inflammatory diseases. Inhibitors targeting JNK2 are being explored as potential therapeutic agents for these conditions. For example, JNK2 inhibitors have shown promise in reducing tumor growth and improving outcomes in preclinical models of cancer .
