SAMD13 Human
Description
SAMD13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The SAMD13 gene is located on chromosome 1 and encodes a protein that contains a SAM domain. The SAM domain is a conserved protein module found in a variety of proteins involved in diverse biological processes, including signal transduction, transcriptional regulation, and cellular differentiation. The SAM domain facilitates protein-protein interactions, which are crucial for the protein’s function.
SAMD13 is predicted to enable chromatin binding activity and histone binding activity. It is involved in the negative regulation of transcription, DNA-templated processes, and is active in the nucleus . The protein encoded by SAMD13 is believed to play a role in regulating gene expression by interacting with chromatin and histones, thereby influencing the transcriptional activity of specific genes.
The SAMD13 gene is part of a larger family of SAM domain-containing proteins, which have evolved through gene duplication events. These proteins are conserved across various species, indicating their importance in fundamental cellular processes. The evolutionary conservation of SAM domains suggests that they play a critical role in maintaining cellular homeostasis and responding to environmental stimuli .
While the specific physiological functions of SAMD13 are still being studied, its role in chromatin and histone binding suggests that it may be involved in various cellular processes, including cell cycle regulation, DNA repair, and apoptosis. Mutations or dysregulation of SAMD13 could potentially lead to various diseases, although more research is needed to fully understand its clinical implications.
Human recombinant SAMD13 is used in research to study its function and interactions with other proteins. Recombinant proteins are produced through genetic engineering techniques, allowing scientists to investigate the protein’s structure, function, and role in cellular processes. These studies can provide insights into the molecular mechanisms underlying various diseases and identify potential therapeutic targets.
In summary, SAMD13 is a crucial protein involved in regulating gene expression through its interactions with chromatin and histones. Its evolutionary conservation and potential clinical relevance make it an important subject of ongoing research.
