S100 Calcium Binding Protein A15 (S100A15) is a member of the S100 protein family, which is characterized by the presence of two EF-hand calcium-binding motifs. These proteins are involved in a variety of intracellular and extracellular functions, including regulation of protein phosphorylation, enzyme activities, cell growth and differentiation, and the inflammatory response.
S100A15, like other S100 proteins, has a structure that allows it to bind calcium ions, which is crucial for its function. The binding of calcium induces a conformational change in the protein, enabling it to interact with target proteins and influence various cellular processes. S100A15 is known to play a role in the regulation of inflammatory responses and has been implicated in various skin conditions.
Recombinant S100A15 refers to the protein that has been produced through recombinant DNA technology. This involves inserting the gene encoding S100A15 into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities. The recombinant protein is then purified for use in research and therapeutic applications.
Recombinant S100A15 is used extensively in research to study its role in inflammation and skin diseases. It is also used to investigate the mechanisms by which S100 proteins interact with other cellular components and to develop potential therapeutic interventions for conditions involving dysregulated inflammation.