Rubella Virus Capsid
Escherichia Coli.
Sterile Filtered clear solution.
Protein is >95% pure as determined by 10% PAGE (coomassie staining).
Description
The E.Coli derived recombinant Rubella Virus Capsid is a 35kDa protein which is fused to a His tag in N-terminus.
Product Specs
Escherichia Coli.
Purified by proprietary chromatographic technique.
Immunoassay.
Product Science Overview
Rubella virus (RUBV) is a positive-strand RNA virus belonging to the genus Rubivirus in the Matonaviridae family . It is an airborne human pathogen that typically causes mild measles-like symptoms in children and adults. However, RUBV infection during pregnancy can lead to severe consequences, including miscarriage or congenital rubella syndrome (CRS), which involves long-term birth defects .
The rubella virus capsid protein is a multifunctional protein that plays a crucial role in the virus’s life cycle. It is involved in the assembly and packaging of the viral genome into a compact nucleocapsid structure . The capsid protein is also known for its anti-apoptotic properties, which help the virus evade the host’s immune response by preventing programmed cell death (apoptosis) of infected cells .
Recombinant rubella virus capsid protein is a laboratory-produced version of the natural protein. It is typically expressed in systems such as Saccharomyces cerevisiae (yeast) and is used in various research applications, including SDS-PAGE, ELISA, and Western Blotting . The recombinant protein retains the functional properties of the natural capsid protein, making it a valuable tool for studying the virus’s biology and developing diagnostic assays.
Recent studies have provided significant insights into the molecular and structural aspects of the rubella virus capsid protein. These studies have highlighted the protein’s role in virus assembly, genome packaging, and interaction with host cell components . Understanding these mechanisms is essential for developing targeted therapies and vaccines against rubella and related viruses.
