RTP4 Human

RTP4 is a probable chaperone protein that facilitates the trafficking and functional cell surface expression of some GPCRs. It is particularly known for promoting the functional expression of the bitter taste receptor TAS2R16 and the opioid receptor heterodimer OPRD1-OPRM1 . This function is vital for the proper sensory perception of bitter taste and the modulation of opioid receptor activity.

RTP4 is expressed in various tissues, including lymphoid tissue, bone marrow, testis, and skeletal muscle . It is involved in several biological processes, such as the innate immune response, protein ubiquitination, and transmembrane transport . The protein’s expression profile suggests its involvement in diverse cellular functions, including immune system regulation and spermatid development .

RTP4 is predicted to enable olfactory receptor binding activity and is involved in the defense response to viruses . Its role in protein targeting to membranes is crucial for maintaining cellular homeostasis and responding to external stimuli. The protein’s involvement in sensory perception and immune response highlights its importance in both normal physiological functions and disease states .

The study of RTP4 and its interactions with GPCRs has significant implications for understanding various diseases and developing therapeutic interventions. Given its role in immune response and sensory perception, RTP4 could be a potential target for drug development aimed at modulating these pathways. Additionally, its involvement in the functional expression of opioid receptors suggests potential applications in pain management and addiction treatment .