RQCD1 Human

RCD1 Required for Cell Differentiation1 Human Recombinant
Cat. No.
BT13103
Source
Escherichia Coli.
Synonyms
Cell differentiation protein RCD1 homolog, Rcd-1, RQCD1, RCD1, CNOT9, CT129, RCD1+.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

RQCD1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 319 amino acids (1-299 a.a.) and having a molecular mass of 35.7kDa. The RQCD1 is purified by proprietary chromatographic techniques.

Product Specs

Introduction
RQCD1, a novel transcriptional cofactor, plays a crucial role in retinoic acid-induced cell differentiation. It acts by downregulating MYB and JUN-dependent transcription. Additionally, RQCD1 is involved in retinoic acid-regulated lung development.
Description
RQCD1 Human Recombinant is a single, non-glycosylated polypeptide chain with a 20 amino acid His tag at its N-terminus. Produced in E. coli, it encompasses 319 amino acids (1-299 a.a.) and has a molecular weight of 35.7kDa. The purification process involves proprietary chromatographic techniques.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
The RQCD1 solution (1 mg/ml) is supplied in a buffer containing 20mM Tris-HCl (pH 8.0), 0.1M NaCl, 1mM DTT, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended periods, store frozen at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 95.0% as determined by SDS-PAGE analysis.
Synonyms
Cell differentiation protein RCD1 homolog, Rcd-1, RQCD1, RCD1, CNOT9, CT129, RCD1+.
Source
Escherichia Coli.
Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MHSLATAAPV PTTLAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP DLAPMLWHSF GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ.

Product Science Overview

Function and Mechanism

RQCD1 mediates the effects of retinoic acid, a derivative of vitamin A, which is essential for regulating gene expression during cell differentiation. It down-regulates MYB- and JUN-dependent transcription, which are key factors in cell proliferation and differentiation . By modulating these transcription factors, RQCD1 ensures proper cell differentiation and development.

Role in Development

One of the critical roles of RQCD1 is in retinoic acid-controlled lung development . Retinoic acid signaling is crucial for the formation and maturation of the respiratory system, and RQCD1’s involvement in this pathway highlights its importance in developmental biology.

Recombinant RCD1

Recombinant RCD1 is a form of the protein that is produced through recombinant DNA technology. This involves inserting the gene encoding RCD1 into a host organism, such as bacteria or yeast, which then produces the protein. Recombinant proteins are valuable in research and therapeutic applications because they can be produced in large quantities and with high purity.

Applications in Research

Recombinant RCD1 is used in various research applications to study its role in cell differentiation and development. It is also utilized to investigate the mechanisms of retinoic acid signaling and its impact on gene expression. Understanding these processes can provide insights into developmental disorders and potential therapeutic targets.

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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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