RPS5 Human
Description
RPS5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Ribosomal Protein S5 (RPS5) is a crucial component of the 40S subunit of eukaryotic ribosomes. It belongs to a highly conserved family of ribosomal proteins, which play essential roles in the process of translation and protein synthesis. RPS5 is particularly significant due to its involvement in the initiation of translation and its potential implications in various diseases, including cancer and liver disease .
RPS5 is located at the head of the 40S ribosomal subunit and is characterized by its basic nature, containing many arginyl and lysyl residues, with an estimated isoelectric point (pI) of 9.6 . This protein is essential for cell viability and plays a substantial role in the binding of 18S ribosomal RNA (rRNA), which is a critical component of the small ribosomal subunit .
The primary function of RPS5 is to facilitate the assembly of the ribosome and the translation of messenger RNA (mRNA) into proteins. It achieves this by interacting with other ribosomal proteins and rRNA to form a functional ribosome. Additionally, RPS5 has been implicated in non-ribosomal functions, such as the regulation of cell growth and proliferation .
Recent studies have highlighted the potential role of RPS5 in various diseases. For instance, alterations in the expression of RPS5 have been associated with liver disease and certain types of cancer . The protein’s involvement in these conditions is thought to be related to its role in translation initiation and its interactions with other cellular components.
In cancer, RPS5 may contribute to tumorigenesis by affecting the synthesis of proteins that regulate cell growth and division. Similarly, in liver disease, changes in RPS5 expression could impact the production of proteins necessary for liver function and regeneration .
Human recombinant RPS5 is a form of the protein that is produced using recombinant DNA technology. This involves inserting the gene encoding RPS5 into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities. Recombinant RPS5 is used in various research applications to study its structure, function, and role in diseases.
The availability of human recombinant RPS5 has facilitated numerous studies aimed at understanding the molecular mechanisms underlying its functions and interactions. These studies have provided valuable insights into the protein’s role in translation and its potential as a therapeutic target for diseases .
