RPS19 Human
Description
Product Specs
Product Science Overview
Ribosomal Protein S19 (RPS19) is a crucial component of the small ribosomal subunit, specifically the 40S subunit in eukaryotic cells. It plays a significant role in the synthesis of proteins by facilitating the translation of messenger RNA (mRNA) into polypeptides. The recombinant form of RPS19, produced through genetic engineering techniques, is used in various research and therapeutic applications.
RPS19 is one of the 80 different ribosomal proteins that make up the ribosome, which also includes four RNA species. It is localized at the beak of the 40S ribosomal subunit . The primary function of RPS19 is to assist in the assembly and stability of the ribosome, ensuring efficient and accurate translation of mRNA.
Mutations in the gene encoding RPS19 have been identified in approximately 25% of patients with Diamond-Blackfan Anemia (DBA), a rare congenital erythroblastopenia . This condition is characterized by a failure to produce red blood cells, leading to severe anemia. The exact mechanism by which RPS19 mutations cause DBA is still under investigation, but it is believed to involve disruptions in ribosome biogenesis and function.
RPS19 is essential for erythropoiesis, the process by which red blood cells are produced. Studies have shown that RPS19 expression decreases during terminal erythroid differentiation . This suggests that RPS19 plays a role in the early stages of erythropoiesis, and its proper function is critical for the development of red blood cells.
Recent research has uncovered novel immunosuppressive properties of RPS19. It has been found to interact with the complement C5a receptor 1 (C5aR1) on tumor-infiltrating myeloid-derived suppressor cells (MDSCs) . This interaction promotes tumor growth by facilitating the recruitment of these cells to tumors and inducing the production of immunosuppressive cytokines. Consequently, RPS19 is being explored as a potential target for anticancer therapy to enhance antitumor T cell responses .
The recombinant form of RPS19 is produced using genetic engineering techniques, where the gene encoding RPS19 is inserted into a suitable expression system, such as bacteria or yeast. This allows for the large-scale production of RPS19 for research and therapeutic purposes. Recombinant RPS19 is used in studies to understand its role in ribosome function, erythropoiesis, and its potential as a therapeutic target in cancer treatment.
