RPS13 Human

RPS13 belongs to the S15P family of ribosomal proteins and is a part of the 40S subunit of the ribosome . The ribosome itself is a large ribonucleoprotein complex responsible for translating mRNA into proteins. During the assembly of the small subunit (SSU) processome in the nucleolus, RPS13, along with other ribosomal proteins and biogenesis factors, associates with nascent pre-rRNA to facilitate RNA folding, modifications, rearrangements, and cleavage .

The expression of the RPS13 gene is regulated at multiple levels, including transcription, translation, and splicing . Interestingly, RPS13 has been shown to regulate its own gene expression through a feedback mechanism at the splicing step. This autoregulation involves the inhibition of intron 1 excision from its pre-mRNA, thereby controlling the levels of RPS13 protein within the cell .

RPS13 is associated with several biological pathways, including viral mRNA translation and nervous system development . Dysregulation of ribosomal protein genes, including RPS13, can lead to various critical consequences such as malignant transformation, apoptosis, and developmental malformations . Additionally, RPS13 has been identified as a potential universal reference gene for transcript level studies across different human normal and tumor types .

Human recombinant RPS13 is widely used in research to study ribosome assembly, protein synthesis, and gene regulation mechanisms. Its role in feedback regulation and involvement in various cellular processes make it a valuable tool for understanding the complexities of gene expression and protein synthesis.