RPL12 Human

Ribosomal proteins are integral to the structure and function of ribosomes. The ribosome itself is composed of two subunits: the small 40S subunit and the large 60S subunit. rpL12 is part of the large 60S subunit and is involved in the formation of the ribosomal stalk, a structure critical for the interaction of the ribosome with translation factors .

One of the unique aspects of rpL12 is its distinct nuclear import pathway. Unlike most ribosomal proteins that are imported into the nucleus via multiple transport receptors (karyopherins or importins), rpL12 primarily uses the importin 11 pathway . This pathway is crucial for the nuclear translocation of rpL12 from its site of synthesis in the cytoplasm to the nucleus, where ribosome assembly occurs .

The recombinant production of rpL12 involves the expression of the human RPL12 gene in a suitable host system, such as bacteria or yeast. This process allows for the large-scale production of rpL12, which can be used for various research and therapeutic applications. Recombinant rpL12 is often used in studies to understand its role in ribosome function and its potential implications in diseases related to ribosomal dysfunction.

Research on rpL12 has significant implications for understanding ribosome biogenesis and function. Mutations or dysregulation of ribosomal proteins, including rpL12, can lead to various diseases, collectively known as ribosomopathies. These conditions often result in defects in protein synthesis, leading to a range of clinical manifestations.