RDBP Human
Description
RDBP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
RNA-binding proteins (RBPs) are essential regulators of gene expression, playing crucial roles in various cellular processes. They interact with RNA molecules to control their production, maturation, localization, modification, translation, and degradation . The RD RNA Binding Protein (Human Recombinant) is a specific type of RBP that has been engineered for research and therapeutic purposes.
RNA-binding proteins typically contain well-defined RNA-binding domains (RBDs) that engage RNA in a sequence- and/or structure-specific manner . These domains include RNA recognition motifs (RRMs), K homology (KH) domains, and zinc finger domains, among others. The RD RNA Binding Protein is designed to mimic the natural human RBP, ensuring it retains the ability to bind RNA with high specificity and affinity.
The RD RNA Binding Protein is involved in several key cellular processes:
- Alternative Splicing: RBPs, including the RD RNA Binding Protein, regulate the splicing of pre-mRNA, leading to the production of different protein isoforms from a single gene .
- mRNA Stability: By binding to specific RNA sequences, RBPs can influence the stability and degradation of mRNA molecules, thereby controlling the levels of proteins produced in the cell .
- Translation Regulation: RBPs can also affect the translation of mRNA into proteins by interacting with the translation machinery or by modulating the accessibility of mRNA to ribosomes .
The human recombinant version of the RD RNA Binding Protein is invaluable in research due to its ability to precisely mimic the natural protein’s functions. It allows scientists to study the protein’s role in various cellular processes and its interactions with RNA in a controlled environment. Additionally, it has potential therapeutic applications, such as in the treatment of diseases caused by dysregulation of RNA-binding proteins.
Alterations in the expression or function of RBPs, including the RD RNA Binding Protein, have been linked to several human diseases. These include muscular atrophies, neurological disorders, and various cancers . Understanding the mechanisms by which RBPs contribute to these diseases can lead to the development of targeted therapies.
