RCHY1 Human
Description
Product Specs
Product Science Overview
The RCHY1 gene is located on chromosome 4q21.1 and spans approximately 32 kb of DNA, comprising 9 exons . The gene encodes a protein of 261 amino acids with a molecular weight of around 32 kDa . The protein contains both a RING-H2 domain and a CHY zinc finger domain, which are essential for its function as an E3 ubiquitin-protein ligase .
RCHY1 is primarily known for its role as an E3 ubiquitin-protein ligase, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Some of its key targets include:
- Tumor protein p53 (TP53): RCHY1 promotes the ubiquitination and degradation of p53, a crucial tumor suppressor protein .
- Histone deacetylase 1 (HDAC1): Involved in chromatin remodeling and gene expression regulation .
- Cyclin-dependent kinase inhibitor 1B (CDKN1B): Plays a role in cell cycle regulation .
RCHY1’s activity is crucial for maintaining cellular homeostasis and regulating cell cycle progression . It is also involved in the ribosome-associated quality control (RQC) pathway, which ensures the degradation of incompletely synthesized nascent chains from stalled ribosomes .
RCHY1 is expressed at varying levels across different tissues. Higher expression levels are observed in the liver, testis, and heart, while lower levels are found in the lung, brain, muscle, and spleen . In the context of cancer, RCHY1 is overexpressed in non-small cell lung cancers, where it primarily localizes to the cytoplasm and membrane of malignant cells .
The overexpression of RCHY1 in certain cancers, such as non-small cell lung cancer, suggests its potential role in tumorigenesis . By promoting the degradation of p53, RCHY1 may contribute to the reduction of tumor suppressor functions, thereby facilitating cancer progression . Additionally, RCHY1’s interaction with the androgen receptor (AR) and its involvement in the regulation of AR activity further highlight its significance in cancer biology .
Given its role in regulating key proteins involved in cell cycle and tumor suppression, RCHY1 is a potential target for therapeutic interventions. Inhibiting RCHY1’s ubiquitin ligase activity could stabilize p53 levels and enhance its tumor suppressor functions, offering a promising strategy for cancer treatment .
