RBM11 Human

RNA Binding Motif Protein 11 Human Recombinant
Cat. No.
BT11380
Source
Escherichia Coli.
Synonyms
Splicing regulator RBM11, RNA-binding motif protein 11, RBM11.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

RBM11 Human Recombinant produced in E. coli is a single polypeptide chain containing 304 amino acids (1-281) and having a molecular mass of 34.6kDa. RBM11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
RNA Binding Motif Protein 11 (RBM11), a member of the RBM family, contains one RNA recognition motif. Proteins in the RBM gene family have an RNA binding motif and are involved in regulating apoptosis. RBM11 is found in various tissues, including the testis, kidney, spleen, brain, spinal cord, and mammary gland. Alternative splicing results in two isoforms of RBM11.
Description
Recombinant human RBM11, produced in E. coli, is a single polypeptide chain with a molecular weight of 34.6 kDa. It comprises 304 amino acids, spanning from position 1 to 281. A 23-amino acid His-tag is fused to the N-terminus of RBM11. Purification is achieved using proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The RBM11 solution is provided at a concentration of 1 mg/ml and is formulated in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.4 M Urea, and 10% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, it is recommended to store the product frozen at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is advised for long-term storage. Repeated freezing and thawing should be avoided.
Purity
The purity of the product is greater than 85% as determined by SDS-PAGE analysis.
Synonyms
Splicing regulator RBM11, RNA-binding motif protein 11, RBM11.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMFPAQEE ADRTVFVGNL EARVREEILY ELFLQAGPLT KVTICKDREG KPKSFGFVCF KHPESVSYAI ALLNGIRLYG RPINVQYRFG SSRSSEPANQ SFESCVKINS HNYRNEEMLV GRSSFPMQYF PINNTSLPQE YFLFQKMQWH VYNPVLQLPY YEMTAPLPNS ASVSSSLNHV PDLEAGPSSY KWTHQQPSDS DLYQMTAPLP NSASVSSSLN HVPDLEAGPS SYKWTHQQPS DSDLYQMNKR KRQKQTSDSD SSTDNNRGNE CSQKFRKSKK KKRY.

Product Science Overview

Gene and Protein Structure

The RBM11 gene is located on chromosome 21 and is a protein-coding gene. The protein itself is involved in various cellular processes, primarily related to RNA metabolism. It enables poly (U) RNA binding activity and protein homodimerization activity . The protein is located in nuclear specks, which are subnuclear structures involved in the regulation of gene expression .

Function and Mechanism

RBM11 plays a crucial role in the regulation of alternative mRNA splicing via the spliceosome. It acts upstream of or within the cellular response to oxidative stress . The protein is known to antagonize SRSF1-mediated BCL-X splicing, which may affect the choice of alternative 5’ splice sites by binding to specific sequences in exons . This function is particularly important during neuron and germ cell differentiation .

Clinical Significance

RBM11 has been associated with various diseases, including papillary cystadenocarcinoma . The dysregulation of RBM proteins, including RBM11, has been linked to the occurrence and development of cancers . Understanding the mechanisms of these proteins in tumorigenesis and development is essential for identifying new therapeutic targets and prognostic markers .

Research and Applications

The study of RBM11 and other RBM proteins is ongoing, with a focus on their roles in RNA metabolism, including splicing, transport, translation, and stability . These proteins are crucial for various biological activities and are involved in multiple post-transcriptional regulation processes .

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THE BIOTEK
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