Resistin Rat
Escherichia Coli.
Cysteine-rich secreted protein FIZZ3, Adipose tissue-specific secretory factor, ADSF, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, RSTN, XCP1, RETN1, MGC126603, MGC126609.
Sterile Filtered White lyophilized (freeze-dried) powder.
Greater than 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Description
Resistin Rat Recombinant produced in E.Coli is disulfide-linked homodimer consisting of 2x95 amino acid polypeptide chains and having a molecular mass of approximately 20.2kDa.
Resistin is purified by proprietary chromatographic techniques.
Product Specs
Cysteine-rich secreted protein FIZZ3, Adipose tissue-specific secretory factor, ADSF, C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 2, RSTN, XCP1, RETN1, MGC126603, MGC126609.
Escherichia Coli.
MPSMSLCPMD EAISKKINQD FSSLLPAAMK NTVLHCWSVS SRGRLASCPE GTTVTSCSCG SGCGSWDVRE DTMCHCQCGS IDWTAARCCT LRVGS.
Product Science Overview
Resistin is an 11 kDa or 12.5 kDa secretory protein consisting of 94 and 108 amino acids in mice and humans, respectively . The structure of resistin comprises a carboxy-terminal disulfide-rich β-sandwich “head” domain with positive electrostatic surfaces and an amino-terminal α-helical “tail” segment with negative electrostatic potential .
In rodents, resistin is primarily expressed in adipocytes, whereas in humans, it is predominantly expressed in leukocytes . This difference in expression patterns between species has implications for its physiological roles.
1. Metabolic Regulation: Resistin was originally proposed as a novel adipocytokine involved in insulin resistance and type 2 diabetes in mice . It decreases insulin sensitivity, contributing to the development of metabolic disorders.
2. Inflammation: In humans, resistin is considered a pro-inflammatory molecule that plays a regulatory role in many chronic inflammatory diseases, metabolic diseases, infectious diseases, and cancers . It increases the production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-12 through the regulation of the NF-κB signaling pathway .
3. Immune Modulation: Resistin has been shown to enhance the expansion of regulatory T cells (Tregs) through the modulation of dendritic cells . This suggests that resistin plays a role in the immune response by influencing the activity of immune cells.
4. Host Defense: Recent studies have highlighted resistin’s role as a host defense peptide of innate immunity . It exhibits wide-spectrum antimicrobial activity, modulates immunity, and limits microbial product-induced inflammation .
The understanding of resistin’s participation in host defense mechanisms is still limited, but ongoing research aims to uncover its biological properties, functions, and related mechanisms . This knowledge could provide new insights into the pleiotropic biological functions of resistin and yield promising strategies for developing new antimicrobial therapeutic agents .
