RASSF1A Antibody
Description
Product Specs
Product Science Overview
RASSF1A, one of the primary isoforms, is involved in several critical cellular processes:
- Cell Cycle Regulation: RASSF1A represses cyclin A2 and cyclin D1, leading to cell cycle arrest. This regulation is essential for preventing uncontrolled cell proliferation .
- Microtubule Stability: RASSF1A inhibits histone deacetylase 6 (HDAC6), resulting in increased acetylation of microtubules. Acetylated microtubules are more stable, which is vital for maintaining cell structure and function .
- Apoptosis: RASSF1A interacts with K-Ras to activate the apoptotic MST2-LATS1 pathway. This interaction is crucial for programmed cell death, which helps eliminate damaged or cancerous cells .
RASSF1A is recognized as a tumor suppressor gene. Its loss or altered expression is associated with the development and progression of various cancers. The gene is often inactivated by methylation rather than mutations, which leads to its downregulation in cancer cells . This downregulation contributes to tumorigenesis by allowing uncontrolled cell growth and preventing apoptosis .
Mouse anti-human RASSF1 antibodies are used in research to study the expression and function of RASSF1 in human cells. These antibodies help in detecting the presence of RASSF1 protein in various tissues and can be used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation. By using these antibodies, researchers can gain insights into the role of RASSF1 in different cellular processes and its involvement in cancer .
