RASL12 Human
Description
RASL12 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The RAS-Like Family 12 (RASL12) is a member of the Ras superfamily of small GTPases. These proteins play crucial roles in various cellular processes, including signal transduction, cell growth, and differentiation. The Ras superfamily is known for its involvement in transmitting signals within cells, which ultimately control gene transcription and influence fundamental processes such as cell growth and differentiation .
RASL12, like other members of the Ras superfamily, has a conserved GTP-binding core. This core is essential for its function as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state . The protein’s ability to bind and hydrolyze GTP is critical for its role in signal transduction .
The RASL12 protein is predicted to enable GDP binding activity, GTP binding activity, and GTPase activity. It is involved in signal transduction and is active in the plasma membrane . The protein’s structure, as determined by crystallography, reveals a typical GTPase fold, which is crucial for its function .
RASL12 is involved in various cellular processes, including cell proliferation, differentiation, and survival. It plays a role in the regulation of intracellular signaling pathways that control these processes . The protein is expressed in multiple tissues, including lymphoid tissue, bone marrow, testis, and skeletal muscle .
Mutations in Ras genes, including those in the Ras superfamily, can lead to the production of permanently activated Ras proteins. These mutations can cause unintended and overactive signaling inside the cell, even in the absence of incoming signals. Overactive Ras signaling can ultimately lead to cancer . Therefore, Ras inhibitors are being studied as potential treatments for cancer and other diseases associated with Ras overexpression .
Recombinant RAS-Like Family 12 (Human) is produced using recombinant DNA technology. This involves inserting the gene encoding RASL12 into a suitable expression system, such as bacteria or yeast, to produce the protein in large quantities. Recombinant proteins are used in various research applications, including studying protein function, drug development, and therapeutic interventions .
