RAB34 Human
RAB34, Member RAS Oncogene Family Human Recombinant
Cat. No.
BT8987
Source
E.coli.
Synonyms
RAB34 member RAS oncogene family, RAH, RAB39, Ras-related protein Rab-39, Ras-related protein Rah, ras-related protein Rab-34, NARR, Nine amino-acid residue-repeats.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
RAB34 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 279 amino acids (1-259) and having a molecular mass of 31.2 kDa.
RAB34 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RAB34 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
RAB34 is a protein involved in intracellular transport processes. It plays a role in the recycling of cellular components and the movement of lysosomes. RAB34 is found on the plasma membrane and in endocytic compartments.
Description
This product is a recombinant human RAB34 protein produced in E. coli. It is a single, non-glycosylated polypeptide chain with a molecular weight of 31.2 kDa. The protein sequence includes amino acids 1-259 of the RAB34 protein, with a 20 amino acid His-tag fused to the N-terminus. The protein has been purified using proprietary chromatographic techniques.
Physical Appearance
Clear and colorless liquid, sterile-filtered.
Formulation
The RAB34 protein is supplied in a solution containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl, and 40% glycerol. The protein concentration is 0.5mg/ml.
Stability
For short-term storage (up to 4 weeks), the product can be stored at 4°C. For longer-term storage, it is recommended to store the product at -20°C. Adding a carrier protein like HSA or BSA (0.1%) is recommended for extended storage. Avoid repeated freezing and thawing of the product.
Purity
The purity of the RAB34 protein is greater than 90%, as determined by SDS-PAGE analysis.
Synonyms
RAB34 member RAS oncogene family, RAH, RAB39, Ras-related protein Rab-39, Ras-related protein Rah, ras-related protein Rab-34, NARR, Nine amino-acid residue-repeats.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGIP FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHTKQWLADA LKENDPSSVL LFLVGSKKDL STPAQYALME KDALQVAQEM KAEYWAVSSL TGENVREFFF RVAALTFEAN VLAELEKSGA RRIGDVVRIN SDDSNLYLTA SKKKPTCCP
Product Science Overview
Gene and Protein Information
- Gene Name: RAB34
- Protein Name: Ras-related protein Rab-34
- Gene ID: 83871
- Chromosomal Location: 17q11.2
- Protein Coding: Yes
Function
RAB34 is involved in several cellular processes, including:
- Lysosome Repositioning: It helps in the redistribution of lysosomes to the peri-Golgi region .
- Phagosome Maturation: It plays a role in the maturation of phagosomes that engulf pathogens such as Staphylococcus aureus and Mycobacterium tuberculosis .
- Ciliogenesis: RAB34 is involved in the formation of cilia, which are essential for various cellular functions .
- Hedgehog Signaling: It acts as a positive regulator of hedgehog signaling and regulates ciliary function .
Clinical Significance
Mutations or dysregulation of RAB34 have been associated with various diseases, including:
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
