RAB24 Human

RAB24 is a member of the RAS oncogene family, specifically a small GTPase of the Rab subfamily of Ras-related proteins. These proteins are crucial regulators of intracellular protein trafficking, which involves the movement of proteins within cells to their appropriate destinations .

The RAB24 gene is a protein-coding gene associated with several biological pathways, including the innate immune system and protein metabolism . The gene is located on chromosome 5 and has several aliases, including Ras-Related Protein Rab-24 . The protein encoded by this gene is involved in autophagy-related processes, which are essential for cellular homeostasis and the degradation of unnecessary or dysfunctional cellular components .

RAB24, like other Rab proteins, functions as a molecular switch that cycles between an active GTP-bound state and an inactive GDP-bound state. This cycling is crucial for its role in regulating intracellular trafficking. The protein’s GTPase activity allows it to hydrolyze GTP to GDP, thereby switching from an active to an inactive state .

RAB24 is expressed in various tissues, including lymphoid tissue, bone marrow, testis, skeletal muscle, and several others . Its expression is particularly notable in cells involved in the immune response and protein ubiquitination processes . The protein’s localization within cells is essential for its function in autophagy and intracellular trafficking.

Mutations or dysregulation of the RAB24 gene have been associated with certain diseases, including Bartter Syndrome, Type 2, Antenatal, and Migraine With or Without Aura 1 . Understanding the role of RAB24 in these conditions can provide insights into potential therapeutic targets for these diseases.

Research on RAB24 continues to uncover its various roles in cellular processes and its potential implications in disease. The recombinant form of the human RAB24 protein is used in various research applications to study its function and interactions with other proteins.