RAB22A Human
Ras-related protein Rab-22A, Rab-22, RAB22A, RAB22, MGC16770.
Description
RAB22A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 214 amino acids (1-194 a.a.) and having a molecular mass of 24kDa.
RAB22A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Ras-related protein Rab-22A, Rab-22, RAB22A, RAB22, MGC16770.
MGSSHHHHHH SSGLVPRGSH MALRELKVCL LGDTGVGKSS IVWRFVEDSF DPNINPTIGA SFMTKTVQYQ NELHKFLIWD TAGQERFRAL APMYYRGSAA AIIVYDITKE ETFSTLKNWV KELRQHGPPN IVVAIAGNKC DLIDVREVME RDAKDYADSI HAIFVETSAK NAININELFI EISRRIPSTD ANLPSGGKGF KLRRQPSEPK RSCC.
Product Science Overview
RAB22A, a member of the RAS oncogene family, is a protein-coding gene that plays a crucial role in various cellular processes. This gene encodes a small GTPase, which is part of the RAB family. These proteins are involved in the regulation of intracellular membrane trafficking, including vesicle formation, movement, and fusion.
The RAB22A gene is located on chromosome 20 in humans. The protein encoded by this gene is known as Ras-related protein Rab-22A. It consists of 193 amino acids and has a molecular weight of approximately 21.5 kDa. The protein has a GTP-binding domain, which is essential for its function as a molecular switch.
RAB22A is involved in endocytosis and intracellular protein transport. It mediates the trafficking of transferrin from early endosomes to recycling endosomes. This process is crucial for the proper functioning of cellular activities, including nutrient uptake and receptor recycling. Additionally, RAB22A is required for nerve growth factor (NGF)-mediated endocytosis of the NTRK1 receptor, which is essential for neurite outgrowth.
RAB22A alternates between an active GTP-bound form and an inactive GDP-bound form. This switching mechanism is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). In its active form, RAB22A interacts with various effector proteins to facilitate vesicle movement and fusion.
Mutations or dysregulation of RAB22A have been associated with several diseases. For instance, it has been linked to nephrotic syndrome type 3 and Hermansky-Pudlak syndrome type 2. These conditions highlight the importance of RAB22A in maintaining cellular homeostasis and its potential role in disease pathogenesis.
Recombinant human RAB22A is widely used in research to study its function and role in various cellular processes. It is also utilized in the development of therapeutic strategies for diseases associated with its dysregulation. The availability of recombinant RAB22A allows researchers to conduct in-depth studies on its biochemical properties and interactions with other proteins.
