RAB10 Human
Description
Product Specs
Product Science Overview
RAB10 cycles between an inactive GDP-bound form and an active GTP-bound form. In its active form, it recruits various downstream effectors responsible for vesicle formation, movement, tethering, and fusion . This protein is involved in several critical cellular processes, including:
- Endocytic Recycling: RAB10 is a key regulator of endocytic recycling, especially in the basolateral recycling pathways of polarized epithelial cells . It is required for the recruitment of CNT-1 to endosomal membranes in the intestinal epithelium .
- Protein Transport: It regulates the transport of the SLC2A4/GLUT4 glucose transporter-enriched vesicles to the plasma membrane . Additionally, it is involved in the transport of TLR4, a toll-like receptor, to the plasma membrane, which is important for the innate immune response .
- Neuronal Development: In neurons, RAB10 is involved in axonogenesis through the regulation of vesicular membrane trafficking toward the axonal plasma membrane .
Mutations or dysregulation of RAB10 have been associated with various diseases. For instance, it has been linked to Charcot-Marie-Tooth Disease, Recessive Intermediate B, and Astrocytoma, IDH-Mutant, Grade 2 . Understanding the function and regulation of RAB10 can provide insights into these diseases and potentially lead to the development of targeted therapies.
Recombinant human RAB10 protein is often used in research to study its function and role in various cellular processes. This recombinant protein is typically expressed in E. coli and purified for use in various assays . It is a valuable tool for scientists studying intracellular trafficking, protein transport, and related cellular mechanisms.
