QPRT Antibody

Quinolinate Phosphoribosyltransferase (QPRT) is an enzyme that plays a crucial role in the kynurenine pathway, which is involved in the metabolism of tryptophan. Specifically, QPRT catalyzes the conversion of quinolinic acid to nicotinic acid mononucleotide (NAMN), a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD+) . NAD+ is an essential coenzyme in various metabolic processes, including redox reactions, DNA repair, and cell signaling.

Recent studies have highlighted the significance of QPRT in cancer progression. For instance, QPRT expression has been found to be upregulated in invasive breast cancer and spontaneous mammary tumors in MMTV-PyVT transgenic mice . The enzyme’s activity is linked to enhanced cancer cell migration and invasion, suggesting that QPRT may serve as a potential prognostic indicator and therapeutic target in breast cancer .

Mouse anti-human antibodies are antibodies produced in mice that are specifically designed to target human antigens. These antibodies are widely used in research and clinical diagnostics due to their specificity and ability to bind to human proteins. They are generated by immunizing mice with human antigens, leading to the production of antibodies that can be harvested and purified for various applications.

Mouse anti-human antibodies are commonly used in various laboratory techniques, including:

• Western Blotting: To detect specific proteins in a sample.
• Immunohistochemistry: To visualize the distribution and localization of proteins within tissue sections.
• Flow Cytometry: To analyze the expression of cell surface and intracellular proteins.
• Enzyme-Linked Immunosorbent Assay (ELISA): To quantify the presence of specific proteins in a sample.