PTMS Human

Prothymosin alpha is an unstructured protein with a very low isoelectric point (pI 3.5), making it extremely acidic . The recombinant form of this protein is often produced in Escherichia coli (E. coli) and purified using conventional chromatography techniques . The recombinant human PTMA protein is typically fused to a His-tag at the N-terminus to facilitate purification .

Prothymosin alpha has both intracellular and extracellular functions. It is predominantly a nuclear protein but can also function in the cytoplasm and extracellularly . The specific localization of PTMA within cells, as well as the cell type and status, seemingly determine its function .

PTMA undergoes proteolytic modifications that are crucial for elucidating its interactions with other molecules . These interactions are essential for its roles in various physiological and pathological processes. For instance, PTMA has been shown to mediate immune function by conferring resistance to certain opportunistic infections .

Research has progressively attested to the clinical significance of Prothymosin alpha. It has been implicated in numerous pathological conditions, including various cancers, ischemic stroke, and immunomodulation . Additionally, PTMA variants have been identified with potent anti-HIV activity, highlighting its potential in antiviral therapies .

The differential localization patterns of PTMA in different tissues and cell types warrant further investigations to understand its interactions and proteolytic modifications under both normal and pathological conditions . The recombinant form of PTMA is used extensively in research to study its functions and potential therapeutic applications .