PTGDS Human
Prostaglandin-H2 D-isomerase, Beta-trace protein, Cerebrin-28, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2, PTGDS, PDS, PGD2, LPGDS, L-PGDS.
Description
PTGDS produced in E.Coli is a single, non-glycosylated polypeptide chain containing 189 amino acids (23-190 a.a.) and having a molecular mass of 20.9kDa.
PTGDS is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Prostaglandin-H2 D-isomerase (PTGDS) is a glutathione-independent enzyme responsible for converting prostaglandin H2 into prostaglandin D2. It may play a crucial role in the development and upkeep of the central nervous system and the male reproductive system. As the most abundant protein found in cerebrospinal fluid, PTGDS is believed to act as a chaperone for beta-amyloid, potentially contributing to the formation of amyloid plaques seen in Alzheimer's disease.
The PTGDS produced in E. coli is a single polypeptide chain that lacks glycosylation. It comprises 189 amino acids (specifically, amino acids 23 to 190) and has a molecular weight of 20.9 kDa. The protein includes a 21 amino acid His-tag fused to its N-terminus and is purified using proprietary chromatographic methods.
Prostaglandin-H2 D-isomerase, Beta-trace protein, Cerebrin-28, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2, PTGDS, PDS, PGD2, LPGDS, L-PGDS.
Product Science Overview
Prostaglandin D2 Synthase (PGDS) is an enzyme that plays a crucial role in the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). This enzyme is significant in various physiological processes, including neuromodulation, smooth muscle contraction/relaxation, and inhibition of platelet aggregation .
PGDS is a glutathione-independent enzyme, meaning it does not require glutathione to function. It catalyzes the isomerization of PGH2, a common precursor of prostanoids, to produce PGD2 . PGD2 is involved in several central nervous system (CNS) functions, such as sedation, non-rapid eye movement (NREM) sleep, and may have an anti-apoptotic role in oligodendrocytes .
The gene encoding PGDS is known as PTGDS. It is a protein-coding gene associated with various pathways, including fatty acid metabolism and mammalian disorders of sexual development . The protein itself is a member of the lipocalin family, which is composed of secretory proteins that bind and transport lipophilic small substances .
PGD2 functions as a neuromodulator and a trophic factor in the CNS. It is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation . Additionally, PGD2 has been found to play roles in sleep regulation, pain modulation, and food intake . It is secreted into cerebrospinal fluid (CSF), seminal plasma, and plasma, acting as an extracellular carrier of various substances .
PGDS has been implicated in several diseases, including bronchus cancer and cerebrospinal fluid leak . Its role in the CNS and other physiological processes makes it a potential target for therapeutic interventions. Studies with transgenic mice overexpressing this gene suggest that it may also be involved in the regulation of non-rapid eye movement sleep .
